Document Detail

Changes in amniotic fluid lecithin-sphingomyelin ratio following maternal dexamethasone administration.
MedLine Citation:
PMID:  1173325     Owner:  NLM     Status:  MEDLINE    
The effect of dexamethasone on amniotic fluid lecithin-sphingomyelin (L/S) ratio was measured in 15 fetuses of 34 weeks or less of gestation. Six of the patients presented with premature rupture of the membranes. A rise in the L/S ratio is mature levels (two or more) was observed 24 hours to 11 days after the start of treatment in 12 patients. In 2 patients (one second twin and one anencephalic fetus), no rise in L/S ratio occurred. Of 12 cases whch ended in premature delivery (29 to 35 weeks) only one infant, a second twin delivered at the thirtieth week with a posttreatment L/S ration o1.4 weighing 1,240 grams, developed severe respiratory distress syndrome and died. Tt is suggested that dexamethasome accelerates fetal lung maturation by increasing surfactant synthesis or release, and this may be achieved as early as the twenty-eighth week of pregnancy.
E Caspi; P Schreyer; Z Weinraub; I Bukovsky; I Tamir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  122     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-08-08     Completed Date:  1975-08-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / analysis*,  drug effects
Dexamethasone / pharmacology*
Fetal Membranes, Premature Rupture / metabolism
Infant, Newborn
Phosphatidylcholines / analysis*
Pregnancy Trimester, Third
Prenatal Diagnosis
Respiratory Distress Syndrome, Newborn / diagnosis
Sphingomyelins / analysis*
Reg. No./Substance:
0/Phosphatidylcholines; 0/Sphingomyelins; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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