| Changes in alveolar oxygen and carbon dioxide concentration and oxygen consumption during lung preservation. The maintenance of aerobic metabolism during lung preservation. | |
| | |
MedLine Citation:
|
PMID: 8445927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The lung is the only organ to which oxygen may be supplied after its blood supply is stopped. Before this study, we were not certain whether lung cells were able to maintain aerobic metabolism with the oxygen in the alveoli during preservation. Excised rabbit lungs were used to measure changes in the concentration of oxygen and carbon dioxide in the airway and changes in glucose, glucose-6-phosphate, lactate, adenosine triphosphate, and phosphocreatine levels in the lung tissue during preservation under different conditions. Twenty-seven lungs were flushed with low-potassium dextran electrolyte solution, inflated with room air, and preserved at 1 degree C (n = 8), 10 degrees C (n = 8), or 22 degrees (n = 11) for 4, 12, or 24 hours. Eight additional lungs were inflated with 100% nitrogen and preserved at 10 degrees C for 4 (n = 4) or 24 (n = 4) hours. Oxygen levels decreased and carbon dioxide levels increased in the airway of the lungs that were inflated with room air at rates dependent on the preservation temperature. The increase of carbon dioxide in the lungs that were inflated with 100% nitrogen was very small. When the oxygen was not available in the alveoli, lactate accumulated, and adenosine triphosphate and phosphocreatine decreased in the lung tissue. We concluded that lung cells are able to maintain aerobic metabolism with the oxygen in the alveoli during preservation and that the maintenance of aerobic metabolism may be essential to maintain the optimum viability of preserved lung tissue. |
| | |
Authors:
|
H Date; A Matsumura; J K Manchester; J M Cooper; O H Lowry; J D Cooper |
Related Documents
:
|
3303427 - Effect of nebulised aerosol size on lung deposition in patients with mild asthma. 3060207 - The effects of smoking and silica exposure on pulmonary epithelial permeability: a radi... 14980937 - Functional residual capacity and respiratory mechanics as indicators of aeration and co... 8795317 - Effects of carbon dioxide insufflation for laparoscopic cholecystectomy on the respirat... 1934097 - Electromyographic analysis of muscle action about the shoulder. 18057827 - Age-related changes in ionized calcium-binding adapter molecule 1 immunoreactivity and ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of thoracic and cardiovascular surgery Volume: 105 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 1993 Mar |
Date Detail:
|
Created Date: 1993-04-05 Completed Date: 1993-04-05 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 492-501 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, Washington University School of Medicine, St. Louis, Mo. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
metabolism Aerobiosis Animals Carbon Dioxide / metabolism* Glucose-6-Phosphate Glucosephosphates / metabolism Lactates / metabolism Lactic Acid Lung Transplantation* Organ Preservation* Oxygen / metabolism* Oxygen Consumption* Phosphocreatine / metabolism Pulmonary Alveoli / metabolism* Rabbits Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
5 R01 HL41943/HL/NHLBI NIH HHS; NS-08862/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Glucosephosphates; 0/Lactates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 56-73-5/Glucose-6-Phosphate; 67-07-2/Phosphocreatine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bronchial circulation after experimental lung transplantation. The effect of long-term administratio...
Next Document: Exclusion of the placenta during fetal cardiac bypass augments systemic flow and provides important ...