Document Detail


Changes in alveolar oxygen and carbon dioxide concentration and oxygen consumption during lung preservation. The maintenance of aerobic metabolism during lung preservation.
MedLine Citation:
PMID:  8445927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lung is the only organ to which oxygen may be supplied after its blood supply is stopped. Before this study, we were not certain whether lung cells were able to maintain aerobic metabolism with the oxygen in the alveoli during preservation. Excised rabbit lungs were used to measure changes in the concentration of oxygen and carbon dioxide in the airway and changes in glucose, glucose-6-phosphate, lactate, adenosine triphosphate, and phosphocreatine levels in the lung tissue during preservation under different conditions. Twenty-seven lungs were flushed with low-potassium dextran electrolyte solution, inflated with room air, and preserved at 1 degree C (n = 8), 10 degrees C (n = 8), or 22 degrees (n = 11) for 4, 12, or 24 hours. Eight additional lungs were inflated with 100% nitrogen and preserved at 10 degrees C for 4 (n = 4) or 24 (n = 4) hours. Oxygen levels decreased and carbon dioxide levels increased in the airway of the lungs that were inflated with room air at rates dependent on the preservation temperature. The increase of carbon dioxide in the lungs that were inflated with 100% nitrogen was very small. When the oxygen was not available in the alveoli, lactate accumulated, and adenosine triphosphate and phosphocreatine decreased in the lung tissue. We concluded that lung cells are able to maintain aerobic metabolism with the oxygen in the alveoli during preservation and that the maintenance of aerobic metabolism may be essential to maintain the optimum viability of preserved lung tissue.
Authors:
H Date; A Matsumura; J K Manchester; J M Cooper; O H Lowry; J D Cooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  105     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-05     Completed Date:  1993-04-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-501     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Washington University School of Medicine, St. Louis, Mo.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Aerobiosis
Animals
Carbon Dioxide / metabolism*
Glucose-6-Phosphate
Glucosephosphates / metabolism
Lactates / metabolism
Lactic Acid
Lung Transplantation*
Organ Preservation*
Oxygen / metabolism*
Oxygen Consumption*
Phosphocreatine / metabolism
Pulmonary Alveoli / metabolism*
Rabbits
Time Factors
Grant Support
ID/Acronym/Agency:
5 R01 HL41943/HL/NHLBI NIH HHS; NS-08862/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Glucosephosphates; 0/Lactates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 56-73-5/Glucose-6-Phosphate; 67-07-2/Phosphocreatine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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