Document Detail


Changes in alpha 1-acid glycoprotein serum concentrations and glycoforms in the developing human fetus.
MedLine Citation:
PMID:  1842905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
alpha 1-Acid glycoprotein concentrations and reactivity to concanavalin A were measured in maternal and fetal serum and amniotic fluid obtained from 24 women undergoing diagnostic cordocentesis at 20 to 33 wk gestation and in 30 additional fetal sera (19 to 34 weeks gestation). Maternal alpha 1-acid glycoprotein serum levels were five to ten times higher than fetal and amniotic levels. Fetal alpha 1-acid glycoprotein levels were found to increase with advancing gestational age. Using crossed immunoaffino electrophoresis with concanavalin A, alpha 1-acid glycoprotein patterns were identical in maternal serum and amniotic fluid but totally different in fetal serum. The fetal concanavalin A pattern changed progressively during fetal life towards that of the newborn. These data confirm earlier assumptions of fetal synthesis of alpha 1-acid glycoprotein and provide normal reference values for alpha 1-acid glycoprotein in fetal serum. In addition, the specific fetal concanavalin A pattern indicates that the alpha 1-acid glycoprotein glycosylation process during fetal life differs from that in post-natal life.
Authors:
N Seta; B Tissot; F Forestier; J Feger; F Daffos; G Durand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  203     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  167-75     Citation Subset:  IM    
Affiliation:
Laboratoire de Biochimie, UFR des Sciences Pharmaceutiques et Biologiques, Châtenay-Malabry, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / metabolism
Concanavalin A
Female
Fetal Blood / metabolism*
Fetus / metabolism*
Gestational Age
Humans
Immunoelectrophoresis, Two-Dimensional
Orosomucoid / metabolism*
Pregnancy
Chemical
Reg. No./Substance:
0/Orosomucoid; 11028-71-0/Concanavalin A
Comments/Corrections
Comment In:
Clin Chim Acta. 1992 Jun 15;208(1-2):133   [PMID:  1638748 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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