| Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men. | |
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MedLine Citation:
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PMID: 12766098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the effect of moderate intensity physical activity on the interactions between central abdominal adiposity, myocyte lipid content, and insulin action in overweight and obese, sedentary men. RESEARCH DESIGN AND METHODS: Myocyte lipid (biochemical triglyceride and long-chain acyl CoA [LCAC] from vastus lateralis biopsy and soleus and tibialis anterior intramyocellular lipid by (1)H-magnetic resonance spectroscopy), regional body and abdominal fat (dual-energy X-ray absorptiometry and magnetic resonance imaging), serum lipids, insulin action (hyperinsulinemic-euglycemic clamp), and substrate oxidation were measured in 18 nondiabetic, sedentary, and overweight to obese men (aged 37.4 +/- 1.3 years and BMI 30.9 +/- 0.7 kg/m(2), range 26.4-37.6) at baseline, after the first two to four bouts of aerobic exercise (55-70% of VO(2max) for 40 min/session), and at completion of 4.1 +/- 0.2 exercise sessions/week for 9.7 +/- 0.5 weeks (postexercise measurements performed 24-36 h after the last exercise bout). RESULTS: Mean whole body insulin-stimulated glucose uptake and basal fat oxidation rate increased 16 and 41%, respectively, after two to four bouts of exercise, without further increase at program end. Mean aerobic capacity increased 11%, and central abdominal fat decreased 5% at program end, but myocyte lipid levels were not significantly changed. Posttraining increases in insulin-stimulated glucose uptake were predicted by increase in aerobic capacity (r = 0.726, P = 0.001) and magnitude of reduction in visceral fat (r = -0.544, P = 0.02) and not by changes in myocyte lipid or LCAC levels. CONCLUSIONS: These results suggest that in overweight and obese sedentary men, increase in insulin sensitivity with moderate intensity exercise is predicted by improvement in aerobic capacity and reduction in visceral fat but is independent of myocyte triglyceride or LCAC levels. |
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Authors:
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Seng Khee Gan; Adamandia D Kriketos; Bronwyn A Ellis; Campbell H Thompson; Edward W Kraegen; Donald J Chisholm |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes care Volume: 26 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-26 Completed Date: 2004-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 1706-13 Citation Subset: IM |
Affiliation:
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Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen Acyl Coenzyme A / metabolism Adipose Tissue / anatomy & histology* Adult Blood Glucose / metabolism Body Composition Exercise / physiology* Glucose Clamp Technique Humans Lipid Metabolism* Lipids / blood Magnetic Resonance Imaging Male Middle Aged Muscle Cells / metabolism* Muscle, Skeletal / physiopathology* Obesity / physiopathology* Oxidation-Reduction Oxygen Consumption / physiology* Questionnaires Regression Analysis Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Acyl Coenzyme A; 0/Blood Glucose; 0/Lipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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