Document Detail


Changes in activity of the renin-angiotensin system of the rat by induction of acute inflammation.
MedLine Citation:
PMID:  2644507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensinogen is the precursor of biologically active peptide angiotensin II and its hepatic synthesis is increased by the induction of acute inflammation. Studies were carried out to know whether the rise in plasma angiotensinogen is actually involved in the activity of the renin-angiotensin system during acute inflammation. The plasma level of angiotensinogen in rats was increased to 2.5 times the normal level 16 h after the induction of acute inflammation by administration of lipopolysaccharide (LPS). The plasma renin concentration (PRC) was decreased to about 40% of the normal level concomitantly with a reduction of plasma renin activity (PRA) at 4 h after LPS administration. In contrast, 16 h after LPS injection, when plasma angiotensinogen showed a high level and PRC had recovered to the normal range, PRA was increased to 1.7 times the normal level. These results indicate that acute inflammation induced by LPS causes a biphasic change in the generation of angiotensin I, i.e., an early decrease depending upon the reduction of PRC and later increase depending upon elevation of the angiotensinogen concentration.
Authors:
R Ohtani; Y Ohashi; K Muranaga; N Itoh; H Okamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  44     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1989  
Date Detail:
Created Date:  1989-03-16     Completed Date:  1989-03-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-41     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease / blood
Angiotensin I / blood*
Angiotensinogen / blood*
Animals
Inflammation / blood*
Lipopolysaccharides
Male
Rats
Rats, Inbred F344
Renin / blood
Renin-Angiotensin System* / drug effects
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 11002-13-4/Angiotensinogen; 9041-90-1/Angiotensin I; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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