| Changes in activity of the renin-angiotensin system of the rat by induction of acute inflammation. | |
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MedLine Citation:
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PMID: 2644507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensinogen is the precursor of biologically active peptide angiotensin II and its hepatic synthesis is increased by the induction of acute inflammation. Studies were carried out to know whether the rise in plasma angiotensinogen is actually involved in the activity of the renin-angiotensin system during acute inflammation. The plasma level of angiotensinogen in rats was increased to 2.5 times the normal level 16 h after the induction of acute inflammation by administration of lipopolysaccharide (LPS). The plasma renin concentration (PRC) was decreased to about 40% of the normal level concomitantly with a reduction of plasma renin activity (PRA) at 4 h after LPS administration. In contrast, 16 h after LPS injection, when plasma angiotensinogen showed a high level and PRC had recovered to the normal range, PRA was increased to 1.7 times the normal level. These results indicate that acute inflammation induced by LPS causes a biphasic change in the generation of angiotensin I, i.e., an early decrease depending upon the reduction of PRC and later increase depending upon elevation of the angiotensinogen concentration. |
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Authors:
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R Ohtani; Y Ohashi; K Muranaga; N Itoh; H Okamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 44 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-03-16 Completed Date: 1989-03-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 237-41 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease
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blood Angiotensin I / blood* Angiotensinogen / blood* Animals Inflammation / blood* Lipopolysaccharides Male Rats Rats, Inbred F344 Renin / blood Renin-Angiotensin System* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 11002-13-4/Angiotensinogen; 9041-90-1/Angiotensin I; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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