Document Detail

Changes in activity of the renin-angiotensin system of the rat by induction of acute inflammation.
MedLine Citation:
PMID:  2644507     Owner:  NLM     Status:  MEDLINE    
Angiotensinogen is the precursor of biologically active peptide angiotensin II and its hepatic synthesis is increased by the induction of acute inflammation. Studies were carried out to know whether the rise in plasma angiotensinogen is actually involved in the activity of the renin-angiotensin system during acute inflammation. The plasma level of angiotensinogen in rats was increased to 2.5 times the normal level 16 h after the induction of acute inflammation by administration of lipopolysaccharide (LPS). The plasma renin concentration (PRC) was decreased to about 40% of the normal level concomitantly with a reduction of plasma renin activity (PRA) at 4 h after LPS administration. In contrast, 16 h after LPS injection, when plasma angiotensinogen showed a high level and PRC had recovered to the normal range, PRA was increased to 1.7 times the normal level. These results indicate that acute inflammation induced by LPS causes a biphasic change in the generation of angiotensin I, i.e., an early decrease depending upon the reduction of PRC and later increase depending upon elevation of the angiotensinogen concentration.
R Ohtani; Y Ohashi; K Muranaga; N Itoh; H Okamoto
Related Documents :
7720907 - Serum total renin is elevated in women with polycystic ovarian syndrome.
750157 - Effect of saralasin and serum in myohaemoglobinuric acute renal failure of rats.
16625237 - Plasma adrenomedullin level and development of hypertension.
2647527 - Ovarian renin production in vitro and in vivo: characterization and clinical correlation.
20471317 - Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood p...
3098157 - Serum thyroid hormones and thyroid hormone binding proteins in patients with completed ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  44     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1989  
Date Detail:
Created Date:  1989-03-16     Completed Date:  1989-03-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-41     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease / blood
Angiotensin I / blood*
Angiotensinogen / blood*
Inflammation / blood*
Rats, Inbred F344
Renin / blood
Renin-Angiotensin System* / drug effects
Reg. No./Substance:
0/Lipopolysaccharides; 11002-13-4/Angiotensinogen; 9041-90-1/Angiotensin I; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Magnetically controlled targeted micro-carrier systems.
Next Document:  Effect of ethanol on androgen receptors in the anterior pituitary, hypothalamus and brain cortex in ...