Document Detail

Changes in activity of plasma thrombin activatable fibrinolysis inhibitor in pregnancy.
MedLine Citation:
PMID:  15004439     Owner:  NLM     Status:  MEDLINE    
The thrombin activatable fibrinolysis inhibitor (TAFI) is a recently described inhibitor of fibrinolysis. Changes in the concentration of plasma TAFI molecules that are present and functional after activation by thrombin-thrombomodulin complex (TAFI activity) during pregnancy have not previously been studied, and we therefore conducted a present prospective study. Plasma TAFI activity was assayed in 15 healthy non-pregnant women and 176 healthy pregnant women at various stages of gestation. TAFI activity was higher in pregnant than in non-pregnant women. TAFI activity seemed to increase progressively until around 20 weeks of gestation, then maintained a moderately elevated level until delivery, and promptly decreased after delivery.
Takashi Watanabe; Hisanori Minakami; Yoichi Sakata; Shigeki Matsubara; Ikuo Sato; Mitsuaki Suzuki
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Publication Detail:
Type:  Journal Article     Date:  2004-03-05
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  58     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  19-21     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan.
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MeSH Terms
Carboxypeptidase U / blood*
Gestational Age
Prospective Studies
Reg. No./Substance:

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