Document Detail

Changes in Thyroid Function in Ethiopian and Non-Ethiopian Israeli HIV/AIDS Patients.
MedLine Citation:
PMID:  22982789     Owner:  NLM     Status:  Publisher    
Objectives: Whether HIV infection and / or its treatment are associated with impaired thyroid function is controversial, and is thus the focus of this study.Israel has a unique population of HIV/AIDS patients, which is composed of two major subgroups; Ethiopian immigrants, and Israeli patients. We seeked to investigate whether HIV infection or its treatment are risk factors for thyroid dysfunction and whether thyroid function changes over time in these distinct subpopulations.Methods: Serum TSH and free T4 levels were determined in HIV carriers followed at Hadassah-Hebrew University Medical Center HIV clinic and were correlated with clinical and laboratory parameters pertaining to their disease including disease duration, drug therapy, viral load, CD4 count, LDL, and CPK. Serum stored at -20°C from time of referral was tested as well.Results: 121 patients were recruited for this study: 60 Ethiopians and 61 Israeli patients. 4/121 (3%) patients had abnormal thyroid function: 2 subclinical hypothyroidism, 1 overt hypothyroidism and 1 overt hyperthyroidism. Previously stored sera was available for 60/121 patients and revealed 2 additional patients with subclinical hypothyroidism. Throughout the follow up period of 3.2±1.9 years, TSH level remained unchanged in the Israeli cohort, whereas in the Ethiopian cohort TSH level significantly declined.Conclusion: Thyroid function abnormalities are uncommon in Israeli HIV/AIDS patients thus not supporting a need for routine screening. The decline in TSH level in the Ethiopian population over time probably represents a shift from an iodine deficient to an iodine sufficient country.
Avivit Cahn; Irena Chairsky-Segal; Keren Olshtain-Pops; Sholomo Maayan; Dana Wolf; Rivka Dresner-Pollak
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-14
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  -     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-15     Citation Subset:  -    
Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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