| Changes in T-cell responses against human herpesvirus-8 correlate with the disease course of iatrogenic Kaposi's sarcoma in a patient with undifferentiated arthritis. | |
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MedLine Citation:
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PMID: 18639317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To describe the first in-depth analysis of both the T-cell responses against human herpesvirus-8 (HHV-8) and the HHV-8 viral load in 1 patient who developed iatrogenic HHV-8-associated-Kaposi's sarcoma (KS) following immunosuppressive treatment for undifferentiated arthritis and to review the literature on iatrogenic KS (IKS). METHODS: T-cell responses against HHV-8 lytic and latent antigens were analyzed by ex vivo enzyme-linked immunospot (Elispot) and HHV-8 viral load was assessed by quantitative polymerase chain reaction, in sequential peripheral blood samples from a 55-year-old woman who developed skin/mucosal and visceral KS, while receiving treatment with cyclosporine, methotrexate, and methylprednisolone for undifferentiated arthritis. RESULTS: KS may result from HHV-8 infection in patients undergoing immunosuppressive treatment for rheumatic diseases and this is the first case of IKS occurring in undifferentiated arthritis. A role for immune surveillance in the pathogenesis of IKS is supported by the observation of disease regression following discontinuation of immunosuppressive therapy. In a 4-year follow-up, we showed that variations of the virus-specific immune responses but not of the viral load correlated well with the disease course, characterized by 2 remission and subsequent relapse phases, following changes of immunosuppressive therapy. CONCLUSIONS: We have provided evidence of a clear-cut correlation between changes in immunologic markers of HHV-8 infection and the disease course of this viral associated tumor, concomitant with variations of immunosuppressive treatment. Thus, ex vivo enzyme-linked immunospot for HHV-8-specific T-cell responses represents a new tool for the clinical management of rheumatic patients with IKS. |
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Authors:
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Patrizia Barozzi; Leonardo Potenza; Giovanni Riva; Daniela Vallerini; Chiara Quadrelli; Raffaella Bosco; Monica Morselli; Fabio Forghieri; Francesco Volzone; Giulio Rossi; Clodoveo Ferri; Chiara Bonini; Fabio Ciceri; Claudio Bordignon; Denise Whitby; Thomas F Schulz; Giuseppe Torelli; Mario Luppi |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-17 |
Journal Detail:
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Title: Seminars in arthritis and rheumatism Volume: 39 ISSN: 1532-866X ISO Abbreviation: Semin. Arthritis Rheum. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306053 Medline TA: Semin Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 170-5 Citation Subset: IM |
Affiliation:
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Department of Oncology and Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliera Policlinico, Modena, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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blood* Arthritis / complications*, drug therapy Disease Progression* Female Follow-Up Studies Herpesvirus 8, Human / immunology* Humans Iatrogenic Disease Immunosuppressive Agents / adverse effects, therapeutic use Middle Aged Opportunistic Infections / etiology, immunology Sarcoma, Kaposi / etiology, immunology* T-Lymphocytes / immunology* Viral Load |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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