Document Detail

Changes in Staphylococcus aureus density and lesion severity after topical application of povidone-iodine in cases of atopic dermatitis.
MedLine Citation:
PMID:  9438904     Owner:  NLM     Status:  MEDLINE    
A case-control study was performed to examine the efficacy of 10% povidone-iodine solution applied to atopic dermatitis patients. The density of Staphylococcus aureus on the eczematous lesions and the lesion severity before and after the topical application of povidone-iodine were compared. We found a 10-100-fold decrease in the density of S. aureus after povidone-iodine treatment in patients colonizing S. aureus at an initial density of > 1000 CFU/10 cm2. Erythema and exudation also decreased after povidone-iodine treatment in patients colonizing S. aureus at an initial density of > 1000 CFU/10 cm2. The 10% povidone-iodine solution disinfected S. aureus cells when added immediately after the cells were mixed in human plasma; however, 10% povidone-iodine solution only reduced the density of S. aureus cells by 10-100-fold when S. aureus cells were harvested after a 24 h incubation in human plasma. Staphylococcus aureus cells harvested after 24 h incubation in human plasma were often surrounded by fibrin bundles and cells circumscribed by fibrin bundles could not be disinfected with 10% povidone-iodine solution. We suggest that S. aureus cells may produce biofilm-like structures in atopic dermatitis patients and that these structures may help S. aureus cells resist the 10% povidone-iodine treatment.
H Akiyama; J Tada; J Toi; H Kanzaki; J Arata
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of dermatological science     Volume:  16     ISSN:  0923-1811     ISO Abbreviation:  J. Dermatol. Sci.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-03-05     Completed Date:  1998-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9011485     Medline TA:  J Dermatol Sci     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
Department of Dermatology, Okayama University Medical School, Shikata-cho, Japan.
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MeSH Terms
Administration, Topical
Anti-Infective Agents, Local / therapeutic use*
Case-Control Studies
Dermatitis, Atopic / drug therapy*,  microbiology*
Microscopy, Electron
Povidone-Iodine / therapeutic use*
Staphylococcal Skin Infections / drug therapy*
Staphylococcus aureus*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 25655-41-8/Povidone-Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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