| Changes in simple spike activity of some Purkinje cells in the oculomotor vermis during saccade adaptation are appropriate to participate in motor learning. | |
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MedLine Citation:
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PMID: 20220005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adaptation of saccadic eye movements provides an excellent motor learning model to study theories of neuronal plasticity. When primates make saccades to a jumping target, a backward step of the target during the saccade can make it appear to overshoot. If this deception continues for many trials, saccades gradually decrease in amplitude to go directly to the back-stepped target location. We used this adaptation paradigm to evaluate the Marr-Albus hypothesis that such motor learning occurs at the Purkinje (P)-cell of the cerebellum. We recorded the activity of identified P-cells in the oculomotor vermis, lobules VIc and VII. After documenting the on and off error directions of the complex spike activity of a P-cell, we determined whether its saccade-related simple spike (SS) activity changed during saccade adaptation in those two directions. Before adaptation, 57 of 61 P-cells exhibited a clear burst, pause, or a combination of both for saccades in one or both directions. Sixty-two percent of all cells, including two of the four initially unresponsive ones, behaved differently for saccades whose size changed because of adaptation than for saccades of similar sizes gathered before adaptation. In at least 42% of these, the changes were appropriate to decrease saccade amplitude based on our current knowledge of cerebellum and brainstem saccade circuitry. Changes in activity during adaptation were not compensating for the potential fatigue associated with performing many saccades. Therefore, many P-cells in the oculomotor vermis exhibit changes in SS activity specific to adapted saccades and therefore appropriate to induce adaptation. |
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Authors:
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Yoshiko Kojima; Robijanto Soetedjo; Albert F Fuchs |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-04-09 Revised Date: 2011-02-01 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 3715-27 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195-7330, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Adaptation, Physiological / physiology* Animals Cerebellum / physiology* Learning / physiology* Macaca mulatta Male Motor Activity / physiology* Oculomotor Muscles / physiology Purkinje Cells / physiology* Saccades / physiology* Visual Pathways / physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY00745/EY/NEI NIH HHS; EY019258/EY/NEI NIH HHS; P51 RR000166-485152/RR/NCRR NIH HHS; R01 EY000745-37/EY/NEI NIH HHS; R01 EY019258-02/EY/NEI NIH HHS; RR00166/RR/NCRR NIH HHS |
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