Document Detail

Changes in serum adiponectin levels from birth to term-equivalent age are associated with postnatal weight gain in preterm infants.
MedLine Citation:
PMID:  21273794     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adiponectin, one of the adipocytokines, is postulated to play a key role in fetal growth, probably enhancing the growth-promoting effect of insulin through insulin-sensitizing action.
OBJECTIVES AND METHODS: To examine how different intrauterine or postnatal growth patterns relate to adiponectin secretion, we measured serum adiponectin concentrations in 30 appropriate-for-gestational-age (AGA) and 19 small-for-gestational-age (SGA) preterm infants on the first day of life and at term-equivalent age.
RESULTS: The serum levels of adiponectin increased significantly in all preterm infants from birth to term-equivalent age. The adiponectin levels at term-equivalent age were significantly higher in the AGA than in the SGA group [mean (SD) 40.4 (12.3) vs. 28.4 (10.4) μg/ml; p < 0.01] after adjustment for gestational age or term-equivalent body weight. The increase in adiponectin levels from birth to term-equivalent age was significantly higher in the AGA than in the SGA group, and was positively correlated with the weight gain rate (g/kg/day) in the combined groups (r = 0.37, p < 0.01). A multiple regression analysis with the adiponectin increase from birth to term-equivalent age as the dependent variable for all the subjects revealed that only weight gain rate was independently associated with the adiponectin increase.
CONCLUSIONS: Our results suggest that the change in serum adiponectin levels may reflect postnatal growth from birth to term-equivalent age in preterm infants.
Makoto Saito; Kazunori Nishimura; Hiroki Nozue; Yayoi Miyazono; Tomohiro Kamoda
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Publication Detail:
Type:  Journal Article     Date:  2011-01-26
Journal Detail:
Title:  Neonatology     Volume:  100     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-24     Completed Date:  2011-12-07     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  93-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Department of Pediatrics, University of Tsukuba, Tsukuba, Japan.
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MeSH Terms
Adiponectin / blood
Birth Weight / physiology
Gestational Age
Infant, Newborn
Infant, Premature / blood*,  growth & development*,  physiology
Infant, Small for Gestational Age / blood,  growth & development
Longitudinal Studies
Parturition / blood*
Term Birth / blood*
Weight Gain / physiology*
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin

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