| Changes in serum adiponectin levels from birth to term-equivalent age are associated with postnatal weight gain in preterm infants. | |
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MedLine Citation:
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PMID: 21273794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adiponectin, one of the adipocytokines, is postulated to play a key role in fetal growth, probably enhancing the growth-promoting effect of insulin through insulin-sensitizing action. OBJECTIVES AND METHODS: To examine how different intrauterine or postnatal growth patterns relate to adiponectin secretion, we measured serum adiponectin concentrations in 30 appropriate-for-gestational-age (AGA) and 19 small-for-gestational-age (SGA) preterm infants on the first day of life and at term-equivalent age. RESULTS: The serum levels of adiponectin increased significantly in all preterm infants from birth to term-equivalent age. The adiponectin levels at term-equivalent age were significantly higher in the AGA than in the SGA group [mean (SD) 40.4 (12.3) vs. 28.4 (10.4) μg/ml; p < 0.01] after adjustment for gestational age or term-equivalent body weight. The increase in adiponectin levels from birth to term-equivalent age was significantly higher in the AGA than in the SGA group, and was positively correlated with the weight gain rate (g/kg/day) in the combined groups (r = 0.37, p < 0.01). A multiple regression analysis with the adiponectin increase from birth to term-equivalent age as the dependent variable for all the subjects revealed that only weight gain rate was independently associated with the adiponectin increase. CONCLUSIONS: Our results suggest that the change in serum adiponectin levels may reflect postnatal growth from birth to term-equivalent age in preterm infants. |
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Authors:
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Makoto Saito; Kazunori Nishimura; Hiroki Nozue; Yayoi Miyazono; Tomohiro Kamoda |
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Publication Detail:
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Type: Journal Article Date: 2011-01-26 |
Journal Detail:
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Title: Neonatology Volume: 100 ISSN: 1661-7819 ISO Abbreviation: Neonatology Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-24 Completed Date: 2011-12-07 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 101286577 Medline TA: Neonatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 93-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Pediatrics, University of Tsukuba, Tsukuba, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Birth Weight / physiology Female Gestational Age Humans Infant, Newborn Infant, Premature / blood*, growth & development*, physiology Infant, Small for Gestational Age / blood, growth & development Longitudinal Studies Male Parturition / blood* Term Birth / blood* Weight Gain / physiology* |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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