Document Detail


Changes in Respiratory Support of Preterm Infants in the Last Decade: Are We Improving?
MedLine Citation:
PMID:  22222256     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Ventilator-induced lung injury has been recognized as a major contributing factor for bronchopulmonary dysplasia (BPD) in preterm infants. In the last decade, focus has shifted towards a more gentle respiratory approach. Aim: To evaluate whether guideline changes in respiratory management in the delivery room and the unit improved the incidence of BPD in very preterm infants. Methods: Three cohorts of infants <30 weeks of gestation, born at the Leiden University Medical Center in the Netherlands in 1996-1997 (cohort '96), 2003-2004 (cohort '03) and 2008-2009 (cohort '08), were compared retrospectively. The major change was increasing use of continuous positive airway pressure in time, and monitoring the tidal volume during mechanical ventilation in cohort '08. The primary outcome was BPD at 36 weeks. Results: The incidence of BPD did not change from 47% in cohort '96 to 55% in cohort '03 (n.s.), but decreased significantly to 37% in cohort '08 (cohort '96 vs. '08 and cohort '03 vs. '08: p < 0.01). We observed the same effect when only moderate and severe BPD were counted with 27% in cohort '96, 31% in cohort '03 and 14% in '08 (cohort '96 vs. '03: p = n.s., cohort '96 vs. '08: p < 0.01, cohort '03 vs. '08: p < 0.05). The mortality rate was not significantly different between the three cohorts. Conclusion: The incidence of BPD in our cohort of preterm infants has decreased during the last decade and could be due to the changes in respiratory management.
Authors:
E E M Mulder; E Lopriore; M Rijken; F J Walther; A B Te Pas
Related Documents :
22743406 - Health-related quality of life for infants in the neonatal intensive care unit.
22140356 - The contribution of infant, maternal, and family conditions to maternal feeding compete...
22006486 - Docosahexaenoic acid (dha) concentration in very low birth weight newborns receiving a ...
21630426 - Effects of folic acid fortification on spina bifida prevalence in brazil.
19421336 - Infant smiling dynamics and perceived positive emotion.
17697076 - Outcomes of preterm children according to type of delivery onset: a nationwide populati...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-04
Journal Detail:
Title:  Neonatology     Volume:  101     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  247-253     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Update of long-term trends analysis of ambient 8-hour ozone and precursor monitoring data in the Sou...
Next Document:  Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in ...