| Changes in regional brain morphology in neuropsychiatric systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 22467931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Neuropsychiatric lupus (NPSLE) is a severe and potentially life-threatening condition, reported to occur in 25%-70% of patients with systemic lupus erythematosus (SLE). Brain imaging, especially magnetic resonance imaging, is frequently used to diagnose or exclude overt cerebral pathologies such as edema, hemorrhage, and central thrombosis. More advanced imaging techniques have been applied to demonstrate subtle changes in regional cerebral blood flow and brain structure. We investigated changes in regional gray-matter (GM) volume in SLE patients without neurological manifestations and NPSLE patients at an acute stage of the disease. METHODS: Using high-resolution structural images and voxel-based morphometry (VBM), we investigated regional GM volume in 20 NPSLE patients (within 2 weeks of the acute manifestation), 18 SLE patients without neurologic and/or psychiatric manifestations, and 18 healthy controls. RESULTS: VBM analyses revealed several regions of GM atrophy in various parts of the brain in NPSLE and SLE patients. GM atrophy was seen in both groups in the temporal and parietal lobes and was most pronounced in the posterior thalamus bilaterally. Both groups showed an increase in regional GM volume in the posterior parahippocampal gyrus. CONCLUSION: Our data suggest that changes in regional brain morphology are present in acute NPSLE, but also in SLE (as compared to controls), which might be indicative of a subclinical neurodegenerative process. Further research is needed to investigate whether specific neuropsychiatric symptoms are related to these changes. |
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Authors:
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Patricia C Cagnoli; Pia C Sundgren; Anson Kairys; Courtney C Graft; Daniel J Clauw; Stephen Gebarski; W Joseph McCune; Tobias Schmidt-Wilcke |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-04-01 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 39 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-02 Completed Date: 2013-02-04 Revised Date: 2013-03-05 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 959-67 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan 48105, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain / pathology* Female Humans Lupus Vasculitis, Central Nervous System / pathology* Magnetic Resonance Imaging / methods* Male Middle Aged Parahippocampal Gyrus / pathology Parietal Lobe / pathology Posterior Thalamic Nuclei / pathology Temporal Lobe / pathology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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UL1 RR024986/RR/NCRR NIH HHS; UL1RR024986/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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