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Changes in pro-oxidant-antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease.
MedLine Citation:
PMID:  21070760     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVES: In this study we aimed to assess the changes in pro-oxidant-antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease.
DESIGN AND METHODS: Percutaneous coronary interventions (PCI) with either BMS or DES were undertaken for 152 patients (82 in the BMS and 70 in the DES groups respectively). PAB values were measured 24h before and after PCI.
RESULTS: Baseline PAB values were 80.68 (64.98-99.37) and 98.86 (64.70-140.62) for BMS and DES group, respectively, which were not significantly different between the 2 groups (P>0.05). Following PCI, median PAB values decreased to 72.10 (61.40-96.13) and 81.40 (54.15-121.90) in BMS and DES groups, respectively. The reduction was significant in both BMS and DES groups (P<0.05). The changes in PAB values were -2.81 (-12.76 to 2.31) for BMS and -2.82 (-29.88 to 8.93) for DES group, which were not significantly different between the 2 groups (P>0.05).
CONCLUSION: We found that the reported difference in clinical outcomes following DES or BMS implantation cannot be attributed to differences in early changes in oxidative stress induction as assessed by changes in PAB values.
Authors:
Homa Falsoleiman; Mashalla Dehghani; Mohsen Moohebati; Afsoon Fazlinezhad; Mahdi Hassanzadeh Daloee; Daryoush Hamidi Alamdari; Habib Ollah Esmaily; Seyyed Mohammad Reza Parizadeh; Shima Tavallaie; Amir Ali Rahsepar; Roghayeh Paydar; Seyyed Mohammad Reza Kazemi-Bajestani; Hossein Pourghadam-Yari; Parisa Abbasi Parizad; Majid Ghayour-Mobarhan; Gordon A Ferns
Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  Clinical biochemistry     Volume:  44     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Cardiovascular Research Center, Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Science (MUMS), Mashhad, Iran; Department of Cardiology, Faculty of Medicine, MUMS, Mashhad, Iran.
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