| Changes in plasma amino acids during extracorporeal liver support by fractionated plasma separation and adsorption. | |
| | |
MedLine Citation:
|
PMID: 19817727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In patients with liver failure, amino acid dysbalance is common and associated with hepatic encephalopathy. Prometheus is a newly designed extracorporeal liver support system based upon fractionated plasma separation and adsorption (FPSA). We evaluated the influence of FPSA on plasma amino acid patterns in patients with liver failure and hepatic encephalopathy. We studied nine patients with acute-on-chronic liver failure, hepatic encephalopathy, and concomitant renal failure. A single session of FPSA therapy for 5 +/- 1 h was performed in all patients. Twenty-six different plasma amino acids were measured by high-performance liquid chromatography before and after FPSA treatment. Total amino acids as well as Fischer index were calculated. Additionally, a variety of clinical and biochemical parameters were assessed. Before FPSA was started, plasma levels of most amino acids were elevated. Plasma ammonia levels correlated with glutamine levels (P < 0.04). During FPSA, plasma levels of nearly all amino acids significantly decreased except for branched-chain amino acids. The Fischer index improved without reaching statistical significance. FPSA therapy tends to normalize plasma amino acids in patients with combined liver and renal failure. This may contribute to positive pathophysiologic effects, especially on hepatic encephalopathy. However, the clinical significance of these findings needs to be further evaluated. |
| | |
Authors:
|
Kinan Rifai; Anibh Das; Jens Rosenau; Thomas Ernst; Ulrich Kretschmer; Hermann Haller; Danilo Fliser; Michael Peter Manns |
Related Documents
:
|
3519567 - Factors affecting perfusion distribution in canine oleic acid pulmonary edema. 3438737 - Acidic deposition and human exposure to toxic metals. 16472777 - Novel short chain fatty acids restore chloride secretion in cystic fibrosis. 985277 - Free amino acids in human blood plasma during space flights. 17678567 - Co-supplementation of healthy women with fish oil and evening primrose oil increases pl... 3918037 - The metabolic transformations of columbinic acid and the effect of topical application ... |
Publication Detail:
|
Type: Journal Article Date: 2009-10-10 |
Journal Detail:
|
Title: Artificial organs Volume: 34 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-04-27 Completed Date: 2010-07-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
|
Languages: eng Pagination: 166-70 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. rifai.k@gmx.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
blood* Ammonia / blood Chromatography, High Pressure Liquid Extracorporeal Circulation* Female Hepatic Encephalopathy / blood*, complications, surgery Humans Kidney Failure / blood, complications, surgery Liver Failure / blood*, complications, surgery Male Middle Aged Serum Albumin Sorption Detoxification / methods |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Serum Albumin; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fish consumption and school grades in Swedish adolescents: a study of the large general population.
Next Document: Low-Cost Pulsatile Cardiac Assist Device With Compliant Input Chamber.