Document Detail

Changes in NPY and POMC, but not serotonin transporter, following a restricted feeding/repletion protocol in rats.
MedLine Citation:
PMID:  19968967     Owner:  NLM     Status:  MEDLINE    
Serotonin (5-HT) plays a key role in controlling food intake and feeding behaviour and drugs targeting the 5-HT transporter (SERT) at the synaptic cleft have been used to treat feeding related disorders. To test the hypothesis that SERT might be one of the etiologic factors in the rebound hyperphagia that frequently follows the abandoning of calorie restriction diets, brain SERT content and gene expression were assessed in a restricted feeding/repletion (RFR) protocol in female rats. Animals were food-restricted (2 h access to food per day) for 7 consecutive days and then allowed constant free access to food (FAF). This intermittent fasting protocol resulted in rebound hyperphagia. Higher levels of plasma corticosterone during fasting in food-deprived rats were used as an index of hypothalamic-pituitary-adrenal axis activation. Neither brain SERT density nor expression was modified following the RFR protocol. Nevertheless, with respect to other messengers involved in eating behaviour, in the presence of low plasma leptin levels, an increase in NPY expression and a parallel decrease in POMC expression were observed in the hypothalamic arcuate nucleus of rats killed just before rebound hyperphagia. Food-restricted animals provide a tool for the further study of neurochemical alterations and for the development of new drugs to treat alterations that may occur in humans when dieting is abandoned.
Nuria Lauzurica; Luis Garc?a-Garc?a; Sheila Pinto; Jos? A Fuentes; Mercedes Delgado
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-05
Journal Detail:
Title:  Brain research     Volume:  1313     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  103-12     Citation Subset:  IM    
Copyright Information:
Copyright 2009. Published by Elsevier B.V.
Unidad de Cartograf?a Cerebral, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.
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MeSH Terms
Arcuate Nucleus / physiology
Brain / physiology*
Corticosterone / blood
Diet, Reducing
Fasting / blood,  physiology*
Feeding Behavior / physiology*
Gene Expression
Hyperphagia / blood,  etiology,  metabolism
Leptin / blood
Neuropeptide Y / genetics,  metabolism*
Pro-Opiomelanocortin / genetics,  metabolism*
Rats, Sprague-Dawley
Serotonin Plasma Membrane Transport Proteins / genetics,  metabolism*
Time Factors
Reg. No./Substance:
0/Leptin; 0/Neuropeptide Y; 0/Serotonin Plasma Membrane Transport Proteins; 0/Slc6a4 protein, rat; 50-22-6/Corticosterone; 66796-54-1/Pro-Opiomelanocortin

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