| Changes in Lipid Profiles in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy (LSG). | |
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MedLine Citation:
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PMID: 20859769 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has evolved as a primary weight loss surgery. This study provides changes in lipid profiles in obese patients 1 year after LSG. METHODS: A retrospective analysis of patients who underwent LSG from June 2004 to June 2008 provided data on demographics, body mass index (BMI) changes, co-morbidities, and medication changes. We compared lipid profiles, and the relationship between the lipid profiles and pre-operative weight, BMI, and weight loss. Proportion changes for all variables were also assessed. Lipid profiles for those taking lipid-lowering therapy and patients receiving no medication were evaluated. RESULTS: Data is presented on 45 patients (58% women) ages 18 to 73 years. Co-morbidities included hypertension (19), hyperlipidemia (22), and diabetes (13). One year after LSG, weight decreased from 161.4 ± 34.3 to 112.9 ± 25.6 kg (p < 0.01). BMI decreased from 57.5 ± 9.6 to 39.9 ± 7.1 kg/m(2) (p < 0.01). Patients with elevated triglycerides decreased from 17 to 8 (p < 0.01) while patients with elevated cholesterol increased from 13 to 15. High-density lipoprotein cholesterol (HDL) increased from 48.4 to 54.5 mg/dl (p < 0.01) and triglycerides (TG) decreased from 141.7 to 109.3 mg/dl (p < 0.01). TC/HDL and TG/HDL ratios also, decreased significantly (p < 0.01). There were no changes for total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). TG/HDL changes correlated with pre-op weight (r = 0.363, p < 0.05). CONCLUSIONS: One year after LSG, significant weight loss and improvements in HDL and TG levels, TC/HDL and TG/HDL ratios were observed. TC and LDL levels were unchanged. |
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Authors:
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Feng Zhang; Gladys Witt Strain; Wen Lei; Gregory F Dakin; Michel Gagner; Alfons Pomp |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obesity surgery Volume: 21 ISSN: 1708-0428 ISO Abbreviation: Obes Surg Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: United States |
Other Details:
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Languages: eng Pagination: 305-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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