Document Detail

Changes in human meibum lipid composition with age using nuclear magnetic resonance spectroscopy.
MedLine Citation:
PMID:  22169100     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Human tear film stability decreases with increasing age. In this study, the changes in meibum composition were measured in search of markers of tear film instability.
METHODS: (1)H NMR nuclear magnetic resonance (NMR) spectra of 43 normal donors aged 1 to 88 years were acquired.
RESULTS: Compared with meibum from adolescents and adults, meibum from infants and children contains less CH(3) and C═C groups and an increased aldehyde-to-lipid hydroperoxide ratio.
CONCLUSIONS: It is reasonable that tear film stability is higher in infants than in adults. Their meibum contains less CH(3) and C═C groups and higher levels of protein, and as a result, the lipid is more ordered because of the tighter and stronger lipid-lipid interactions. For water to evaporate, it must first pass through the tight lipid-lipid barrier. For tears to break up, lipid-lipid interactions must be broken. It is reasonable that because the lipid-lipid interactions are stronger in infants' and children's tears compared with those of adolescents and adults, the tear film in the younger groups is more stable and provides a better barrier to evaporation than does the tear film of adults. Lipid saturation could be the critical feature in meibum that stabilizes tears in infants.
Douglas Borchman; Gary N Foulks; Marta C Yappert; Sarah E Milliner
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-31
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  53     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-02     Completed Date:  2012-03-27     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  475-82     Citation Subset:  IM    
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Child, Preschool
Lipids / analysis*
Magnetic Resonance Spectroscopy / methods*
Meibomian Glands / chemistry*
Middle Aged
Young Adult
Grant Support
EY017094-01/EY/NEI NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Short-term interventions on wards fail to reduce preanalytical errors: results of two prospective co...
Next Document:  Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its appli...