| Changes in human meibum lipid composition with age using nuclear magnetic resonance spectroscopy. | |
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MedLine Citation:
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PMID: 22169100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Human tear film stability decreases with increasing age. In this study, the changes in meibum composition were measured in search of markers of tear film instability. METHODS: (1)H NMR nuclear magnetic resonance (NMR) spectra of 43 normal donors aged 1 to 88 years were acquired. RESULTS: Compared with meibum from adolescents and adults, meibum from infants and children contains less CH(3) and C═C groups and an increased aldehyde-to-lipid hydroperoxide ratio. CONCLUSIONS: It is reasonable that tear film stability is higher in infants than in adults. Their meibum contains less CH(3) and C═C groups and higher levels of protein, and as a result, the lipid is more ordered because of the tighter and stronger lipid-lipid interactions. For water to evaporate, it must first pass through the tight lipid-lipid barrier. For tears to break up, lipid-lipid interactions must be broken. It is reasonable that because the lipid-lipid interactions are stronger in infants' and children's tears compared with those of adolescents and adults, the tear film in the younger groups is more stable and provides a better barrier to evaporation than does the tear film of adults. Lipid saturation could be the critical feature in meibum that stabilizes tears in infants. |
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Authors:
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Douglas Borchman; Gary N Foulks; Marta C Yappert; Sarah E Milliner |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-01-31 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 53 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-02-02 Completed Date: 2012-03-27 Revised Date: 2013-01-09 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 475-82 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA. borchman@louisville.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Aging* Child Child, Preschool Female Humans Infant Lipids / analysis* Magnetic Resonance Spectroscopy / methods* Male Meibomian Glands / chemistry* Middle Aged Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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EY017094-01/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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