Document Detail


Changes in Exercise Capacity in Subjects with Cardiac Asymptomatic Hereditary Hemochromatosis During a Follow-Up After 5 yrs.
MedLine Citation:
PMID:  22311055     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: A long-term effect of hereditary hemochromatosis (HH) on aerobic exercise capacity (AEC) has not been well described. DESIGN: Forty-three HH and 21 volunteer control subjects who were asymptomatic underwent cardiopulmonary exercise testing using the Bruce protocol. AEC was assessed with minute ventilation (V˙E), oxygen uptake (V˙O2), and carbon dioxide production (V˙CO2) at baseline and at a follow-up assessment after 5 yrs. A paired t test was used for analyses of normality data; otherwise, Wilcoxon's signed rank-sum test was used. RESULTS: Thirty-three HH subjects and 18 volunteer control subjects returned for a repeat cardiopulmonary exercise testing at the fifth-year follow-up (80% overall return rate). At the fifth-year follow-up, AEC was not different between the two groups. Compared with baseline measurements, exercise time, peak V˙O2, and the V˙E/V˙CO2 slope did not differ statistically at the fifth-year follow-up between both groups. Iron depletion through phlebotomy for 5 yrs did not significantly affect AEC in newly diagnosed HH subjects at baseline (n = 14) and cardiac arrhythmias during exercise tended to decrease after 5 yrs of therapy in this group. CONCLUSIONS: The AEC of asymptomatic HH subjects treated using conventional therapy is not statistically affected by the disease during a 5-yr period.
Authors:
Yukitaka Shizukuda; Kevin P Smith; Dorothy J Tripodi; Ross Arena; Yu-Ying Yau; Charles D Bolan; Myron A Waclawiw; Susan F Leitman; Douglas R Rosing
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-2
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  -     ISSN:  1537-7385     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (YS, KPS, DJT, DRR), Bethesda, Maryland; Division of Cardiovascular Diseases, University of Cincinnati (YS), Cincinnati, Ohio; Cincinnati VA Medical Center (YS), Cincinnati, Ohio; Department of Orthopaedics, Physical Therapy Program, University of New Mexico (RA), Albuquerque, New Mexico; Department Transfusion Medicine, Clinical Center, National Institutes of Health (Y-YY, SFL), Bethesda, Maryland; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (CDB), Bethesda, Maryland; and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health (MAW), Bethesda, Maryland.
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