| Changes in Exercise Capacity in Subjects with Cardiac Asymptomatic Hereditary Hemochromatosis During a Follow-Up After 5 yrs. | |
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MedLine Citation:
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PMID: 22311055 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: A long-term effect of hereditary hemochromatosis (HH) on aerobic exercise capacity (AEC) has not been well described. DESIGN: Forty-three HH and 21 volunteer control subjects who were asymptomatic underwent cardiopulmonary exercise testing using the Bruce protocol. AEC was assessed with minute ventilation (V˙E), oxygen uptake (V˙O2), and carbon dioxide production (V˙CO2) at baseline and at a follow-up assessment after 5 yrs. A paired t test was used for analyses of normality data; otherwise, Wilcoxon's signed rank-sum test was used. RESULTS: Thirty-three HH subjects and 18 volunteer control subjects returned for a repeat cardiopulmonary exercise testing at the fifth-year follow-up (80% overall return rate). At the fifth-year follow-up, AEC was not different between the two groups. Compared with baseline measurements, exercise time, peak V˙O2, and the V˙E/V˙CO2 slope did not differ statistically at the fifth-year follow-up between both groups. Iron depletion through phlebotomy for 5 yrs did not significantly affect AEC in newly diagnosed HH subjects at baseline (n = 14) and cardiac arrhythmias during exercise tended to decrease after 5 yrs of therapy in this group. CONCLUSIONS: The AEC of asymptomatic HH subjects treated using conventional therapy is not statistically affected by the disease during a 5-yr period. |
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Authors:
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Yukitaka Shizukuda; Kevin P Smith; Dorothy J Tripodi; Ross Arena; Yu-Ying Yau; Charles D Bolan; Myron A Waclawiw; Susan F Leitman; Douglas R Rosing |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
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Title: American journal of physical medicine & rehabilitation / Association of Academic Physiatrists Volume: - ISSN: 1537-7385 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803677 Medline TA: Am J Phys Med Rehabil Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (YS, KPS, DJT, DRR), Bethesda, Maryland; Division of Cardiovascular Diseases, University of Cincinnati (YS), Cincinnati, Ohio; Cincinnati VA Medical Center (YS), Cincinnati, Ohio; Department of Orthopaedics, Physical Therapy Program, University of New Mexico (RA), Albuquerque, New Mexico; Department Transfusion Medicine, Clinical Center, National Institutes of Health (Y-YY, SFL), Bethesda, Maryland; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (CDB), Bethesda, Maryland; and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health (MAW), Bethesda, Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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