| Changes in ECG and enzyme activity in rat heart after myocardial infarction: effect of TPP and MnCl2. | |
| | |
MedLine Citation:
|
PMID: 19043979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Heart infarction is one of the main causes of death in the human population. Assurance of a sufficient level of bioenergetic processes is very important for the heart after infarction. Mn2+ as well as thiamine pyrophosphate (TPP) are positive effectors of the pyruvate dehydrogenase complex (PDH) and the 2-oxoglutarate dehydrogenase complex (OGDH), both of which play a very important role in the Krebs cycle. Thus, we have established the effect of MnCl2 (10mg/kg) and TPP (20mg/kg)--4 injections every 12 h--on the activity of PDH, OGDH, lactate dehydrogenase (LDH) and malate dehydrogenase (MDH). Additionally, we perform an analysis of ECG to affirm the changes in the heart electrophysiology of healthy rats after MnCl2 and TPP treatment. We then analyzed changes in the activity of these enzymes after experimental myocardial infarction in rats. We observed a decrease of OGDH and MDH activity in rat hearts after infarction in comparison with sham-operated rats. Treatment of healthy rats with MnCl2 caused an increase of OGDH activity. Moreover both MnCl2 and TPP caused an increase of PDH activity and a decrease of MDH activity (TPP revealed a stronger effect). We found no changes in LDH activity. Electrocardiography data showed a slight shortening of the QT interval and an enhanced heartbeat rate after treatment with MnCl2. TPP caused only elongation of the QT interval. In conclusion, application of MnCl2 enhanced the activity of some very important enzymes in the respiration process (PDH and OGDH). This effect, connected with enhanced heartbeat and a slightly shortened ventricle relaxation, may have potential application during the key period of convalescence following heart infarction. |
| | |
Authors:
|
A Tylicki; J Czerniecki; A Godlewska; M Kieliszek; T Zebrowski; T Bielawski; B Wojcik |
Related Documents
:
|
7639329 - Collagen remodeling after myocardial infarction in the rat heart. 18025049 - Early nifurtimox-induced biochemical and ultrastructural alterations in rat heart. 10601349 - C-reactive protein and complement are important mediators of tissue damage in acute myo... 7722119 - Dilated cardiomyopathy is associated with an increase in the type i/type iii collagen r... 20406659 - Increased sympathoexcitatory reflex induced by myocardial ischemic nociceptive signalin... 9074699 - Relationship between passive tissue strain and collagen uncoiling during healing of inf... 8820849 - A prophylactic implantable cardioverter-defibrillator? 3320259 - Estimation of myocardial infarct size by electrocardiographic and radionuclide techniques. 10155079 - Intravascular ultrasound imaging of a patent ductus arteriosus in an adult. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of physiology and biochemistry Volume: 64 ISSN: 1138-7548 ISO Abbreviation: J. Physiol. Biochem. Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-12-02 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9812509 Medline TA: J Physiol Biochem Country: Spain |
Other Details:
|
Languages: eng Pagination: 93-101 Citation Subset: IM |
Affiliation:
|
Department of Animal Biochemistry, Institute of Biology, University of Bialystok, Swierkowa 20B, 15-950 Bialystok, Poland. atyl@uwb.edu.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Chlorides / pharmacology* Electrocardiography* Heart* / drug effects, physiopathology Humans Male Manganese Compounds / pharmacology* Myocardial Infarction* / enzymology, physiopathology Myocardium* / enzymology, metabolism Rats Rats, Wistar Thiamine Pyrophosphate / pharmacology* Vitamin B Complex / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Chlorides; 0/Manganese Compounds; 12001-76-2/Vitamin B Complex; 154-87-0/Thiamine Pyrophosphate; 7773-01-5/manganese chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A shop for caretakers: how to improve the quality of life for the caretaker and for the patient
Next Document: Glycemia and insulinemia evaluation after high-sucrose and high-fat diets in lean and overweight/obe...