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Changes in Dipolar Structure of Cardiac Magnetic Field Maps after ST Elevation Myocardial Infarction.
MedLine Citation:
PMID:  22008494     Owner:  NLM     Status:  In-Data-Review    
Background: Pathological changes in cardiac electrophysiology have been investigated in coronary artery disease using magnetocardiography. Aim of this work was to examine the structure of cardiac magnetic field maps (MFM) during ventricular depolarization and repolarization in patients with acute ST elevation myocardial infarction (STEMI). Methods: Magnetocardiograms were recorded in 39 healthy subjects and 97 patients who had been successfully revascularized after STEMI. Using the Karhunen-Loeve transform, 12 eigenmaps were constructed for six intervals within the QT interval of each subject's signal-averaged data. The relative information content of the eigenmaps was compared between STEMI patients and healthy subjects. Results: Relative nondipolar content was between 0.03% and 0.52% higher in the STEMI group, (P < 0.001 for the repolarization intervals). Information content of the first dipolar eigenmap in the STEMI group was reduced by 2.6%-11.7% (P < 0.001 for the repolarization intervals). STT interval was best able to discriminate between groups: area-under-the-curve for nondipolar content was 85.8% (P < 0.001), for the first eigenmap 91.7% (P < 0.001). Severity of infarction was reflected in lower STT interval map 1 content for patients with anterior versus posterior infarction (83%± 11% vs. 87%± 10%, P < 0.05), with wall motion disturbances (84%± 11% vs. 92%± 7%, P < 0.001) and with microvascular obstruction (81%± 12% vs. 87%± 10%, P < 0.05). Regression analysis showed that patients with lower ejection fraction tended to have less information content (P < 0.001). Conclusion: STEMI is associated with a loss of spatial coherence during repolarization, as quantified by principal component analysis of cardiac MFM. Ann Noninvasive Electrocardiol 2011;16(4):379-387.
Peter Van Leeuwen; Birgit Hailer; Alexander Beck; Gregor Eiling; Dietrich Grönemeyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  16     ISSN:  1542-474X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-87     Citation Subset:  IM    
Copyright Information:
©2011, Wiley Periodicals, Inc.
Department of Biomagnetism, Grönemeyer Institute for Microtherapy, University Witten/Herdecke, Bochum, Germany Department of Internal Medicine, Philippusstift, Essen, Germany Department of Cardiology, Grönemeyer Institute for Microtherapy, University Witten/Herdecke, Bochum, Germany.
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