Document Detail


Changes in DNA synthesis rate in the Schwann cell lineage in vivo are correlated with the precursor--Schwann cell transition and myelination.
MedLine Citation:
PMID:  7506619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the development of the rat sciatic nerve extensive proliferation of glial cells occurs, and there is a very substantial rearrangement of the cytoarchitecture as axons and Schwann cells assume relationships which lead to the formation of the myelinated and unmyelinated axons characteristic of adult nerve. The maturation of Schwann cells from Schwann cell precursors and the matching of Schwann cell numbers to axons is an important part of this process. We have therefore studied the proliferation of Schwann cell precursors and Schwann cells during the development of the rat sciatic nerve from embryonic day 14 to postnatal day 28 by combining bromodeoxyuridine injections of rats with double-label immunohistochemical techniques. The results reveal that DNA synthesis occurs in both Schwann cell precursors and Schwann cells throughout early nerve development. The labelling index is already substantial at embryonic day 14, but from embryonic day 17, when essentially all the glial cells have converted from precursor to Schwann cell phenotype, it rises sharply, peaking between embryonic day 19 and 20 before declining precipitously in the early postnatal period. This rapid decline in DNA synthesis coincides with the appearance of the myelin protein P0, and in individual cells DNA synthesis is incompatible with the expression of P0 protein. Nonmyelin-forming Schwann cells, which mature later in development, continue to synthesize DNA until at least postnatal day 15, but by day 28 essentially all Schwann cells in the nerve are quiescent.
Authors:
H J Stewart; L Morgan; K R Jessen; R Mirsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  5     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-02-15     Completed Date:  1994-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1136-44     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Developmental Biology, University College, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Antigens / analysis
Cell Adhesion Molecules, Neuronal / metabolism
Cell Division
Cell Line
DNA / biosynthesis*
Myelin P0 Protein
Myelin Proteins / metabolism
Myelin Sheath / physiology*
Rats
Rats, Sprague-Dawley
Schwann Cells / cytology,  metabolism*
Sciatic Nerve / embryology
Stem Cells / physiology*
Chemical
Reg. No./Substance:
0/Antigens; 0/Cell Adhesion Molecules, Neuronal; 0/Myelin P0 Protein; 0/Myelin Proteins; 9007-49-2/DNA

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