Document Detail

Changes in copeptin and bioactive vasopressin in runners with and without hyponatremia.
MedLine Citation:
PMID:  21519298     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate changes in both the N-terminal (arginine vasopressin; AVP) and C-terminal (copeptin) fragments of the vasopressin prohormone before, during, and after an ultramarathon race and to assess vasopressin and copeptin concentrations in runners with and without hyponatremia.
DESIGN: Observational study.
SETTING: Three trials (2 sodium balance and 1 hyponatremia treatment) in 2 separate approximately 160-km footraces [Western States Endurance Run (WSER) and Javelina Jundred (JJ100)].
PARTICIPANTS: Six hyponatremic and 20 normonatremic runners; 19 finishers with 7 completing 100 km.
MAIN OUTCOME MEASURES: Plasma AVP ([AVP]p), copeptin ([copeptin]p), sodium ([Na]p), and protein (%plasma volume change; %PV) concentrations.
RESULTS: In the WSER Sodium Trial, a 3-fold prerace to postrace increase in both [AVP]p (0.7 ± 0.4 to 2.7 ± 1.9 pg/mL; P < 0.05) and [copeptin]p (10.3 ± 12.5 to 28.2 ± 16.3 pmol/L; nonsignificant) occurred, despite a 2 mEq/L decrease in [Na]p (138.7 ± 2.3 to 136.7 ± 1.6 mEq/L; NS). A significant correlation was noted between [AVP]p and [copeptin]p postrace (r = 0.82; P < 0.05). In the WSER Treatment Trial, despite the presence of hyponatremia pretreatment versus posttreatment ([Na]p = 130.3 vs 133.5 mEq/L, respectively), both [AVP]p (3.2 vs 2.1 pg/mL) and [copeptin]p (22.5 vs 24.9 pmol/L) were well above the detectable levels. A significant correlation was noted between [AVP]p and [copeptin]p 60 minutes after treatment (r = 0.94; P < 0.05). In the JJ100 Sodium Trial, significant correlations were found between [copeptin]p change and %PV change (r = -0.34; P < 0.05) and between [AVP]p change and [Na]p change (r = 0.39; P < 0.05) but not vice-versa.
CONCLUSIONS: [Copeptin]p seems to be a reliable surrogate of stimulated [AVP]p during exercise. Nonosmotic vasopressin stimulation occurs during ultradistance running. [Copeptin]p may better reflect chronic (%PV) vasopressin secretion under conditions of endurance exercise.
Tamara Hew-Butler; Martin D Hoffman; Kristin J Stuempfle; Ian R Rogers; Nils G Morgenthaler; Joseph G Verbalis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine     Volume:  21     ISSN:  1536-3724     ISO Abbreviation:  Clin J Sport Med     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-17     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9103300     Medline TA:  Clin J Sport Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-7     Citation Subset:  IM    
Exercise Science Program, School of Health Sciences, Oakland University, Rochester, Michigan. USA.
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MeSH Terms
Blood Proteins / physiology
Blood Volume / physiology
Glycopeptides / blood,  physiology*
Hyponatremia / blood,  physiopathology*
Middle Aged
Physical Endurance / physiology
Running / physiology*
Sodium / blood,  physiology
Vasopressins / blood,  physiology*
Grant Support
Reg. No./Substance:
0/Blood Proteins; 0/Glycopeptides; 0/copeptins; 11000-17-2/Vasopressins; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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