| Changes in copeptin and bioactive vasopressin in runners with and without hyponatremia. | |
| | |
MedLine Citation:
|
PMID: 21519298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate changes in both the N-terminal (arginine vasopressin; AVP) and C-terminal (copeptin) fragments of the vasopressin prohormone before, during, and after an ultramarathon race and to assess vasopressin and copeptin concentrations in runners with and without hyponatremia. DESIGN: Observational study. SETTING: Three trials (2 sodium balance and 1 hyponatremia treatment) in 2 separate approximately 160-km footraces [Western States Endurance Run (WSER) and Javelina Jundred (JJ100)]. PARTICIPANTS: Six hyponatremic and 20 normonatremic runners; 19 finishers with 7 completing 100 km. MAIN OUTCOME MEASURES: Plasma AVP ([AVP]p), copeptin ([copeptin]p), sodium ([Na]p), and protein (%plasma volume change; %PV) concentrations. RESULTS: In the WSER Sodium Trial, a 3-fold prerace to postrace increase in both [AVP]p (0.7 ± 0.4 to 2.7 ± 1.9 pg/mL; P < 0.05) and [copeptin]p (10.3 ± 12.5 to 28.2 ± 16.3 pmol/L; nonsignificant) occurred, despite a 2 mEq/L decrease in [Na]p (138.7 ± 2.3 to 136.7 ± 1.6 mEq/L; NS). A significant correlation was noted between [AVP]p and [copeptin]p postrace (r = 0.82; P < 0.05). In the WSER Treatment Trial, despite the presence of hyponatremia pretreatment versus posttreatment ([Na]p = 130.3 vs 133.5 mEq/L, respectively), both [AVP]p (3.2 vs 2.1 pg/mL) and [copeptin]p (22.5 vs 24.9 pmol/L) were well above the detectable levels. A significant correlation was noted between [AVP]p and [copeptin]p 60 minutes after treatment (r = 0.94; P < 0.05). In the JJ100 Sodium Trial, significant correlations were found between [copeptin]p change and %PV change (r = -0.34; P < 0.05) and between [AVP]p change and [Na]p change (r = 0.39; P < 0.05) but not vice-versa. CONCLUSIONS: [Copeptin]p seems to be a reliable surrogate of stimulated [AVP]p during exercise. Nonosmotic vasopressin stimulation occurs during ultradistance running. [Copeptin]p may better reflect chronic (%PV) vasopressin secretion under conditions of endurance exercise. |
| | |
Authors:
|
Tamara Hew-Butler; Martin D Hoffman; Kristin J Stuempfle; Ian R Rogers; Nils G Morgenthaler; Joseph G Verbalis |
Related Documents
:
|
10368348 - Sodium-free fluid ingestion decreases plasma sodium during exercise in the heat. 514078 - Effect of endurance exercise training on plasma pancreatic polypeptide concentration du... 9848628 - Clearance of tracer albumin from peritoneal cavity to plasma at low intraperitoneal vol... 9244368 - Differences in the change in the time course of plasma endothelin-1 and endothelin-3 le... 21697718 - Type v collagen genotype and exercise-related phenotype relationships: a novel hypothesis. 2534528 - Trunk strength during asymmetric trunk motion. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine Volume: 21 ISSN: 1536-3724 ISO Abbreviation: Clin J Sport Med Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-02 Completed Date: 2011-08-17 Revised Date: 2013-01-29 |
Medline Journal Info:
|
Nlm Unique ID: 9103300 Medline TA: Clin J Sport Med Country: United States |
Other Details:
|
Languages: eng Pagination: 211-7 Citation Subset: IM |
Affiliation:
|
Exercise Science Program, School of Health Sciences, Oakland University, Rochester, Michigan. USA. hew@oakland.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Athletes Blood Proteins / physiology Blood Volume / physiology Female Glycopeptides / blood, physiology* Humans Hyponatremia / blood, physiopathology* Male Middle Aged Physical Endurance / physiology Running / physiology* Sodium / blood, physiology Vasopressins / blood, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
UL1 TR000101/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 0/Glycopeptides; 0/copeptins; 11000-17-2/Vasopressins; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Blood Exposure at the 2010 International Federation of Football Association World Cup: Time for Univ...
Next Document: Survey Study of Members of the Canadian Orthopaedic Association on the Natural History and Treatment...