| Changes in body weight and metabolic indexes in overweight breast cancer survivors enrolled in a randomized trial of low-fat vs. reduced carbohydrate diets. | |
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MedLine Citation:
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PMID: 21058203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Overweight status is common among women breast cancer survivors and places them at greater risk for metabolic disorders, cardiovascular morbidity, and breast cancer recurrence than nonoverweight survivors. Efforts to promote weight control in this population are needed. The objective of this research was to evaluate the effect of low-fat or low-carbohydrate diet counseling on weight loss, body composition, and changes in metabolic indexes in overweight postmenopausal breast cancer survivors. Survivors (n = 40) were randomized to receive dietitian counseling for a low-fat or a reduced carbohydrate diet for 6 mo. Weight and metabolic measures, including glucose, insulin, HbA1c, HOMA, lipids, hsCRP, as well as blood pressure were measured at baseline, 6, 12 and 24 wk. Dietary intake of fat and carbohydrate was reduced by 24 and 76 g/day, respectively. Weight loss averaged 6.1 (± 4.8 kg) at 24 wk and was not significantly different by diet group; loss of lean mass was also demonstrated. All subjects demonstrated improvements in total/HDL cholesterol ratio, and significant reductions in HbA1c, insulin, and HOMA. Triglycerides levels were significantly reduced only in the low-carbohydrate diet group (-31.1 ± 36.6; P = 0.01). Significant improvements in weight and metabolic indexes can be demonstrated among overweight breast cancer survivors adherent to either a carbohydrate- or fat-restricted diet. |
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Authors:
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Cynthia A Thomson; Alison T Stopeck; Jennifer W Bea; Ellen Cussler; Emily Nardi; Georgette Frey; Patricia A Thompson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition and cancer Volume: 62 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2011-03-08 Revised Date: 2011-03-25 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: England |
Other Details:
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Languages: eng Pagination: 1142-52 Citation Subset: IM |
Affiliation:
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University of Arizona, Tucson, Arizona 85721, USA. cthomson@email.arizona.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure Body Composition Body Mass Index Breast Neoplasms / complications, therapy* Diet, Carbohydrate-Restricted* Diet, Fat-Restricted* Female Humans Metabolic Syndrome X / epidemiology*, prevention & control* Middle Aged Nutritional Sciences / education Overweight / diet therapy*, physiopathology Patient Education as Topic Pilot Projects Postmenopause Remission Induction Risk Factors Time Factors Weight Loss* |
| Grant Support | |
ID/Acronym/Agency:
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P30-CA23074/CA/NCI NIH HHS; R25T CA-78447/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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