Document Detail

Changes in Body Weight After Treatment of Primary Hypothyroidism with Levothyroxine.
MedLine Citation:
PMID:  24936556     Owner:  NLM     Status:  Publisher    
Objective: Surprisingly few studies have examined weight change in hypothyroid patients after initiation of levothyroxine (LT4) therapy. Our study aimed to investigate weight change after initiation of treatment for primary hypothyroidism.Methods: Using electronic medical records from Boston Medical Center, Boston, MA, we performed a retrospective cohort study from 1/1/2003-2/1/2011. Adults aged ≥ 18 years with newly-diagnosed primary hypothyroidism with initial thyroid-stimulating hormone (TSH) ≥10mIU/L were identified. Patients with post-surgical hypothyroidism, thyroid cancer, and history of radioactive iodine or head/neck radiation, congestive heart failure, anorexia nervosa, end-stage renal disease, cirrhosis, pregnancy, or prescription weight loss medication use were excluded. TSH and weight at diagnosis and up to 24 months after LT4 initiation were collected. Weight change was assessed at the first post-treatment serum TSH <5mIU/L.Results: A total of 101 patients (mean age 48±15 yrs, 71% women) were included. Initial median (range) TSH was 18.3mIU/L (10.1-710.5) and weight was 79.6kg (41.5-167.5). Post-treatment median (range) TSH was 2.3mIU/L (0.04-5) and weight change at a median of 5 months (1.1-25.6) was -0.1kg (-20.6-7.7). Initial median (range) BMI of 95 patients was 29.3 (19.5-56.1) and the median change in BMI was - 0.1kg/m2 (-7.1-3.3). Only 52% of patients lost weight, with a mean weight loss 3.8±4.4 kg. Gender, race, education, insurance type, age, initial TSH, time to normalization of TSH, and initial weight were not associated with changes in weight or BMI.Conclusion: Contrary to popular belief, there was no significant weight change after initiating LT4 treatment in 101 patients with primary hypothyroidism.
Sun Y Lee; Lewis E Braverman; Elizabeth N Pearce
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-16
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  -     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-19     Citation Subset:  -    
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