| Changes in auditory nerve responses across the duration of sinusoidally amplitude-modulated electric pulse-train stimuli. | |
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MedLine Citation:
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PMID: 20632064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Response rates of auditory nerve fibers (ANFs) to electric pulse trains change over time, reflecting substantial spike-rate adaptation that depends on stimulus parameters. We hypothesize that adaptation affects the representation of amplitude-modulated pulse trains used by cochlear prostheses to transmit speech information to the auditory system. We recorded cat ANF responses to sinusoidally amplitude-modulated (SAM) trains with 5,000 pulse/s carriers. Stimuli delivered by a monopolar intracochlear electrode had fixed modulation frequency (100 Hz) and depth (10%). ANF responses were assessed by spike-rate measures, while representation of modulation was evaluated by vector strength (VS) and the fundamental component of the fast Fourier transform (F(0) amplitude). These measures were assessed across the 400 ms duration of pulse-train stimuli, a duration relevant to speech stimuli. Different stimulus levels were explored and responses were categorized into four spike-rate groups to assess level effects across ANFs. The temporal pattern of rate adaptation to modulated trains was similar to that of unmodulated trains, but with less rate adaptation. VS to the modulator increased over time and tended to saturate at lower spike rates, while F(0) amplitude typically decreased over time for low driven rates and increased for higher driven rates. VS at moderate and high spike rates and degree of F(0) amplitude temporal changes at low and moderate spike rates were positively correlated with the degree of rate adaptation. Thus, high-rate carriers will modify the ANF representation of the modulator over time. As the VS and F(0) measures were sensitive to adaptation-related changes over different spike-rate ranges, there is value in assessing both measures. |
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Authors:
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Ning Hu; Charles A Miller; Paul J Abbas; Barbara K Robinson; Jihwan Woo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-15 |
Journal Detail:
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Title: Journal of the Association for Research in Otolaryngology : JARO Volume: 11 ISSN: 1438-7573 ISO Abbreviation: J. Assoc. Res. Otolaryngol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2011-03-03 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 100892857 Medline TA: J Assoc Res Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 641-56 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. ninghu@houghear.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Adaptation, Physiological / physiology* Animals Cats Cochlear Nerve / physiology* Electric Stimulation* Evoked Potentials, Auditory / physiology Fourier Analysis Models, Animal Outcome Assessment (Health Care) Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01-DC006478/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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