| Changes in auditory feedback connections determine the severity of speech processing deficits after stroke. | |
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MedLine Citation:
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PMID: 22442088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared brain structure and function in two subgroups of 21 stroke patients with either moderate or severe chronic speech comprehension impairment. Both groups had damage to the supratemporal plane; however, the severe group suffered greater damage to two unimodal auditory areas: primary auditory cortex and the planum temporale. The effects of this damage were investigated using fMRI while patients listened to speech and speech-like sounds. Pronounced changes in connectivity were found in both groups in undamaged parts of the auditory hierarchy. Compared to controls, moderate patients had significantly stronger feedback connections from planum temporale to primary auditory cortex bilaterally, while in severe patients this connection was significantly weaker in the undamaged right hemisphere. This suggests that predictive feedback mechanisms compensate in moderately affected patients but not in severely affected patients. The key pathomechanism in humans with persistent speech comprehension impairments may be impaired feedback connectivity to unimodal auditory areas. |
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Authors:
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Thomas M Schofield; Will D Penny; Klaas E Stephan; Jennifer T Crinion; Alan J Thompson; Cathy J Price; Alexander P Leff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-23 Completed Date: 2012-05-18 Revised Date: 2012-10-01 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 4260-70 Citation Subset: IM |
Affiliation:
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Wellcome Trust Centre for Neuroimaging, University College London, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods Adult Aged Aged, 80 and over Auditory Cortex* / blood supply, pathology, physiopathology Auditory Pathways / blood supply, pathology, physiopathology Brain Mapping* Comprehension Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Models, Statistical Nonlinear Dynamics Oxygen / blood Speech Disorders / etiology*, pathology* Speech Perception / physiology* Stroke / complications* |
| Grant Support | |
ID/Acronym/Agency:
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075765//Wellcome Trust; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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