| Changes in apolipoprotein B100-containing lipoprotein metabolism due to an estrogen plus progestin oral contraceptive: a stable isotope kinetic study. | |
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MedLine Citation:
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PMID: 20200333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Oral contraceptives with estrogen plus progestin are likely to influence apolipoprotein B (apoB)-containing lipoprotein metabolism by changing the expression of different enzymes or receptors that play a major role in this metabolism. However, the precise changes in apoB kinetic parameters induced by oral contraceptives that are now currently used are unknown. OBJECTIVES: We studied the impact of Moneva, containing 30 microg ethinylestradiol and 75 microg gestodene, on the apoB production rate and fractional catabolic rate of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL). DESIGN: Using a 16-h [(13)C]leucine infusion, we performed an apoB kinetic study in nine normolipidemic women before and 3 months after beginning Moneva. RESULTS: On Moneva, serum triglycerides increased moderately (+12%, P = 0.04) in the fed state, whereas serum LDL remained unchanged. LDL particles were richer in triglycerides in women on Moneva (7.5 +/- 1.5 vs. 4.3 +/- 1.0% of total LDL mass, P < 0.01). The apoB production rate of VLDL, IDL, and LDL increased by 49 (P = 0.04), 55 (P = 0.05), and 51% (P = 0.01), respectively. The fractional catabolic rate of apoB in LDL increased by 36% (P = 0.04). Consequently, the serum LDL apoB pool size remained unchanged (26.49 +/- 6.98 vs. 23.96 +/- 5.37 mg/kg). CONCLUSION: Oral contraception with ethinylestradiol plus gestodene induces an increase in the production rate of apoB-containing lipoproteins all along the VLDL-->IDL-->LDL cascade. The increased production rate of apoB in LDL is counterbalanced by a higher fractional catabolic rate of apoB in LDL, thus precluding an increase in the concentration of atherogenic LDL particles. |
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Authors:
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Laurence Duvillard; Guillaume Dautin; Emmanuel Florentin; Jean-Michel Petit; Philippe Gambert; Bruno Verg?s |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-03 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 2140-6 Citation Subset: AIM; IM |
Affiliation:
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Institut National de la Sant? et de la Recherche M?dicale Unit? 866, Universit? de Bourgogne, Facult? de M?decine, Dijon F-21000, France. laurence.duvillard@chu-dijon.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Apolipoprotein B-100 / blood, metabolism* Cholesterol / blood Cholesterol, HDL / blood, drug effects Cholesterol, LDL / blood, drug effects Contraceptives, Oral / therapeutic use* Ethinyl Estradiol / therapeutic use* Female Humans Kinetics Leucine / blood Lipoproteins, LDL / blood*, drug effects Norpregnenes / therapeutic use* Triglycerides / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein B-100; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Contraceptives, Oral; 0/Lipoproteins, LDL; 0/Norpregnenes; 0/Triglycerides; 57-63-6/Ethinyl Estradiol; 57-88-5/Cholesterol; 60282-87-3/Gestodene; 61-90-5/Leucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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