Document Detail

Changes in 13, 14-dihydro-15-keto-prostaglandin F2alpha levels in saliva during pregnancy, labor and the postpartum period.
MedLine Citation:
PMID:  20178524     Owner:  NLM     Status:  MEDLINE    
AIMS: To examine changes in the levels of 13, 14-dihydro-15-keto-prostaglandin F(2alpha) (PGFM) in saliva during pregnancy, labor and the postpartum period, and to evaluate the relationship between cervical dilatation or contraction interval and salivary PGFM levels during labor.
METHODS: This longitudinal study was conducted in the Department of Obstetrics in a hospital in Japan that has approximately 500 deliveries per year. Maternal and neonatal data were obtained from medical records. Saliva samples were collected during pregnancy (from 35 to 36 weeks gestation), labor and the postpartum period.
RESULTS: Sixty-four healthy pregnant women were recruited and data from 30 subjects were analyzed. Salivary PGFM levels were almost constant during pregnancy, increased as labor progressed and decreased after delivery. Salivary PGFM levels during contraction intervals of 1-2 min were significantly higher than those when contraction intervals were 7-8, 5-6 or 3-4 min.
CONCLUSIONS: PGFM levels in saliva significantly increased with labor progression, remained at the highest level until delivery of the placenta, and decreased after delivery. Salivary PGFM levels are related not to cervical dilatation but to contraction interval. It was found that salivary PGFM levels reflected the contraction status of the uterus as delivery progressed.
Kae Nakayama; Megumi Haruna; Masayo Matsuzaki; Kyouichi Sekine; Sachiyo Murashima
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  36     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-24     Completed Date:  2010-06-01     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
Department of Midwifery and Women's Health, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
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MeSH Terms
Dinoprost / analogs & derivatives*,  analysis
Labor Stage, First
Labor Stage, Third
Labor, Obstetric*
Longitudinal Studies
Postpartum Period*
Pregnancy Trimester, Third
Saliva / chemistry*
Uterine Contraction
Reg. No./Substance:
551-11-1/Dinoprost; 69536-60-3/13,14-dihydroxy-15-ketoprostaglandin F2alpha

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