Document Detail

Changes of hepatic morphology during parenteral nutrition with lipid emulsions containing LCT or MCT/LCT quantified by ultrasound.
MedLine Citation:
PMID:  1766047     Owner:  NLM     Status:  MEDLINE    
Fatty infiltration of the liver with cholestasis is one of the complications of total parenteral nutrition (TPN). The cause has not yet been determined. It seems probable, however, that these alterations could be prevented when a mixture of medium- and long-chain triglycerides (MCT/LCT) is used as a fat component instead of the application of long-chain emulsions (LCT) alone. To determine whether this could also be demonstrated morphologically in man, 14 patients needing TPN (25 kcal/kg BW x day, carbohydrate 45%, fat 35%, protein 20%) were examined by ultrasound in order to compare liver size and gray-scale value before and after 7 days of TPN. Seven of the patients were randomly administered a MCT/LCT emulsion as their fat intake, the other seven were exclusively given LCT. There were no changes in liver size and gray-scale value in the MCT/LCT-group, whereas both parameters showed a significant rise in the patients with LCT (size: 10.4 +/- 1.4 to 11.5 +/- 1.4 cm; gray-scale value: 9.3 +/- 1.0 to 11.6 +/- 0.7). These data suggest that TPN, administered with a mixture of MCT/LCT emulsions as fat components, could reduce the risk of hepatic dysfunction such as cholestasis and fatty infiltration of the liver.
H Baldermann; M Wicklmayr; K Rett; P Banholzer; G Dietze; H Mehnert
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  15     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1991 Nov-Dec
Date Detail:
Created Date:  1992-02-20     Completed Date:  1992-02-20     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  601-3     Citation Subset:  IM    
Third Medical Department, Schwabing City Hospital, Munich, Federal Republic of Germany.
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MeSH Terms
Cholestasis, Intrahepatic / etiology,  prevention & control
Fat Emulsions, Intravenous / adverse effects*,  chemistry
Fatty Liver / etiology,  prevention & control
Liver / pathology*,  ultrasonography
Parenteral Nutrition, Total / adverse effects*
Triglycerides / administration & dosage*,  chemistry
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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