Document Detail

Changes of glycolipids dependent on cell density of Ehrlich ascites carcinoma cells.
MedLine Citation:
PMID:  6745256     Owner:  NLM     Status:  MEDLINE    
The glycolipid composition of Ehrlich ascites carcinoma cells was found to depend strongly on the cell density of the suspension. The general trend observed upon dilution of the cell suspension was a reduction of the less complex gangliosides GM3 and GM2 with concomitant increase of the more complex gangliosides, especially GM1. The increase of the content of ganglioside GM1 upon dilution was accompanied by a comparable decrease of the content of its immediate precursor, asialo-GM1, whereas the content of other neutral glycosphingolipids did not change very much. When the cell suspension was diluted with medium conditioned by dense cells the ganglioside profile of the diluted suspension remained similar to that of the dense cell suspension. It is postulated that the medium conditioned with dense cells contains a transferable factor inhibiting sialylation of asialo-GM1.
N V Prokazova; S L Kocharov; G I Shaposhnikova; N D Zvezdina; L D Bergelson
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of biochemistry / FEBS     Volume:  141     ISSN:  0014-2956     ISO Abbreviation:  Eur. J. Biochem.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-09-05     Completed Date:  1984-09-05     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  0107600     Medline TA:  Eur J Biochem     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  527-9     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Ehrlich Tumor / metabolism*,  pathology
Cell Count
Gangliosides / metabolism
Glycolipids / metabolism*
Glycosphingolipids / metabolism
Reg. No./Substance:
0/Gangliosides; 0/Glycolipids; 0/Glycosphingolipids

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