| Changes of ghrelin and leptin levels in plasma by cigarette smoke in rats. | |
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MedLine Citation:
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PMID: 22293417 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Cigarettes smoke (CS) limits food intake and body weight increase. Ghrelin and leptin are hormones regulating appetite and energy balance. While ghrelin increases food intake and causes a positive energy balance, leptin decreases food intake and enhances a negative energy balance. To investigate the possible role of ghrelin and leptin regarding the negative energy balance caused by CS, 10-week old male Wistar rats (n = 10) were exposed to CS from 30 cigarettes twice a day for 5 days a week for four weeks. In the smoking group, food intake and body weight gain were less than those in the non-smoking group (n = 10) during the entire CS exposure. In the smoking group, the plasma levels of acyl ghrelin were significantly higher (75.9 ± 5.1 fmol/ml versus 46.5 ± 3.3 fmol/ml, p < 0.01), while those of leptin were significantly lower than those in the non-smoking group (434.9 ± 41.1 ng/ml versus 744.0 ± 45.4 ng/ml, p < 0.01) after the final CS exposure. However, the plasma des-acyl ghrelin levels were not affected by CS exposure. These results suggested that acyl ghrelin and leptin levels in plasma may change to compensate for the negative energy balance by CS. |
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Authors:
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Koichi Tomoda; Kaoru Kubo; Yasue Nishii; Yoshifumi Yamamoto; Masanori Yoshikawa; Hiroshi Kimura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of toxicological sciences Volume: 37 ISSN: 1880-3989 ISO Abbreviation: J Toxicol Sci Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805798 Medline TA: J Toxicol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 131-8 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Nara Medical University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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