Document Detail

Changes of femoral alkaline phosphatase activity in adult rats treated by sorbitol enriched or vitamin D3 deficient diet.
MedLine Citation:
PMID:  2100897     Owner:  NLM     Status:  MEDLINE    
The effect of vitamin D3-deficiency and dietary sorbitol on serum calcium level, the activity and alkaline phosphatase (AP) pattern in femoral epiphysis were studied. Rats fed a diet supplemented with sorbitol or vitamin D3 showed the same serum calcium concentration and AP activity in serum and femur. Rats fed a vitamin D3-deficient diet displayed decreased serum calcium concentration and increased AP activity both in serum and femur. Four forms of AP were isolated from the femur of these rat groups: of Mr 100,000, 110,000, 130,000 and 165,000. Rats receiving the diet supplemented with sorbitol showed a marked rise in the activity of the Mr 165,000 form, and appearance of a new monomer of 100,000, never formed in two remaining groups.
S Tardivel; H Banide; Y Dupuis; A Ranivosoa; P Fournier; E Zelazowska; Z Porembska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  37     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-08-28     Completed Date:  1991-08-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
Métabolisme Minéral des Mammiféres, EPHE, Physiologie, Faculté de Pharmacie, Châtenay-Malabry, France.
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MeSH Terms
Alkaline Phosphatase / analysis,  chemistry,  metabolism*
Calcium / blood
Electrophoresis, Polyacrylamide Gel
Epiphyses / enzymology*
Molecular Weight
Rats, Inbred Strains
Sorbitol / administration & dosage*,  pharmacology
Vitamin D Deficiency / enzymology*
Reg. No./Substance:
50-70-4/Sorbitol; 7440-70-2/Calcium; EC Phosphatase

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