Document Detail

Changes of exhaled nitric oxide during steroid treatment of childhood asthma.
MedLine Citation:
PMID:  12108850     Owner:  NLM     Status:  MEDLINE    
Exhaled nitric oxide (eNO) is elevated in several inflammatory airway diseases and is significantly reduced by anti-inflammatory treatment with inhaled steroids. The aim of this randomized, open clinical trial was to evaluate eNO in relation to conventional lung function parameters at rest and after exercise during sequential changes of inhaled steroids in children with persistent asthma. The study consisted of a 4 week run-in period, a 4 week washout phase and a randomized treatment period during which only one group was treated again with inhaled budesonide. After run-in, eNO was reduced to normal values, and rose again during washout. In the patients randomized to steroid treatment, eNO was again decreased, whereas it remained unchanged in the untreated patients. Forced expiratory volume in one second and forced vital capacity at rest and after exercise improved significantly after run-in, but showed no difference after randomization. However there was a strong correlation of eNO with patient compliance. Exhaled nitric oxide was able to differentiate between children briefly treated with or without steroids, the conventional lung-function variables however could not. In practice exhaled nitric oxide may thus be a valuable parameter to monitor adherence to steroids, but less suitable to describe physiologically relevant impairments of lung function.
J Beck-Ripp; M Griese; S Arenz; C Köring; B Pasqualoni; P Bufler
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  19     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-10     Completed Date:  2003-01-13     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1015-9     Citation Subset:  IM    
Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage*
Asthma / diagnosis,  drug therapy*,  metabolism*
Biological Markers
Budesonide / administration & dosage*
Forced Expiratory Volume / drug effects
Lung Compliance / drug effects
Nitric Oxide / metabolism*
Vital Capacity / drug effects
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Biological Markers; 10102-43-9/Nitric Oxide; 51333-22-3/Budesonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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