Document Detail


Changes of elastic properties of central arteries during acute static exercise and lower body negative pressure.
MedLine Citation:
PMID:  18066579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this investigation was to determine the acute effects of isometric fatiguing handgrip (IFHG) and lower body negative pressure (LBNP) on indices of central arterial stiffness. Thirteen subjects were studied. Renal blood velocity (Duplex Ultrasound) and blood pressure (Finapres) were monitored during IFHG and LBNP at -30 and -50 mmHg. Radial pulse-wave forms were recorded by applanation tonometry. Central aortic waveforms and other hemodynamic parameters were assessed using the Sphygmocor software. Renal vascular resistance index (RVRI; mean BP/renal blood velocity) was used as index of sympathetic nervous system (SNS) engagement. RVRI increased during both IFHG and LBNP indicating that SNS was engaged; however, BP increased only during the IFHG. Pulse-wave analysis showed that during the IFHG protocol the transit time of the pulse wave decreased and the peripheral pulse pressure/nonaugmented central pulse pressure ratio increased from baseline. Both of these measurements suggest an increase in central large artery stiffness. During LBNP no changes in the indices of central stiffness were noted, in spite of a similar level of sympathetic system engagement. Heart rate increased during both protocols, whereas augmentation index increased during the IFHG protocol and decreased during the LBNP. Our major conclusion was that blood pressure rather than sympathetic activity seems to play the major role in modulating the elastic properties of the central arteries. The decrease in augmentation index during the LBNP protocol can be attributed to the increased heart rate, given that there is a negative correlation between these two parameters.
Authors:
Charalampos Lydakis; Afsana Momen; Cheryl Blaha; Michael Herr; Urs A Leuenberger; Lawrence I Sinoway
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-12-08
Journal Detail:
Title:  European journal of applied physiology     Volume:  102     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  633-41     Citation Subset:  IM    
Affiliation:
Penn State Heart and Vascular Institute, Cardiology, H047, 500 University Drive, Hershey, PA 17033, USA. hlydakis@yahoo.gr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aorta / physiology*
Blood Flow Velocity / physiology
Blood Pressure / physiology
Elasticity
Exercise / physiology*
Female
Hand Strength / physiology*
Heart Rate / physiology
Humans
Kidney / blood supply
Lower Body Negative Pressure*
Male
Radial Artery / physiology
Regional Blood Flow / physiology
Sympathetic Nervous System / physiology
Vascular Resistance / physiology*
Grant Support
ID/Acronym/Agency:
C06 RR016499/RR/NCRR NIH HHS; M01 RR010732/RR/NCRR NIH HHS; P01 HL077670/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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