Document Detail

Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimer's Disease.
MedLine Citation:
PMID:  16781898     Owner:  NLM     Status:  MEDLINE    
Transgenic mice carrying human Amyloid Precursor Protein mutations present amyloid plaque deposition in the brain upon aging. In this study, we characterized the changes of cortex proteome and endogenous Apolipoprotein E in these mice. Differential analysis of two-dimensional electrophoresis images revealed spots altered upon aging, transgene addition and plaque deposition. Alpha-synuclein and cytochrome oxidase polypeptide Va were up-regulated in transgenic mice. Upon aging, expression of ATP synthase alpha, alpha enolase, UMP-CMP kinase, and dihydropyrimidinase like-2 protein was modified. These proteins and their modification probably play a role in the amyloid aggregate formation in these mice.
O Carrette; J A Burgess; P R Burkhard; C Lang; M Côte; N Rodrigo; D F Hochstrasser; J-C Sanchez
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Publication Detail:
Type:  Congresses; Overall     Date:  2006-06-16
Journal Detail:
Title:  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences     Volume:  840     ISSN:  1570-0232     ISO Abbreviation:  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101139554     Medline TA:  J Chromatogr B Analyt Technol Biomed Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Neuroproteomics Group, Department of Structural Biology and Bioinformatics, Geneva University, Faculty of Medicine, Geneva, Switzerland.
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MeSH Terms
Alzheimer Disease / metabolism*
Amino Acid Sequence
Apolipoproteins E / chemistry,  genetics,  metabolism*
Disease Models, Animal*
Electrophoresis, Gel, Two-Dimensional
Mass Spectrometry
Mice, Transgenic
Molecular Sequence Data
Reg. No./Substance:
0/Apolipoproteins E; 0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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