Document Detail


Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimer's Disease.
MedLine Citation:
PMID:  16781898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transgenic mice carrying human Amyloid Precursor Protein mutations present amyloid plaque deposition in the brain upon aging. In this study, we characterized the changes of cortex proteome and endogenous Apolipoprotein E in these mice. Differential analysis of two-dimensional electrophoresis images revealed spots altered upon aging, transgene addition and plaque deposition. Alpha-synuclein and cytochrome oxidase polypeptide Va were up-regulated in transgenic mice. Upon aging, expression of ATP synthase alpha, alpha enolase, UMP-CMP kinase, and dihydropyrimidinase like-2 protein was modified. These proteins and their modification probably play a role in the amyloid aggregate formation in these mice.
Authors:
O Carrette; J A Burgess; P R Burkhard; C Lang; M Côte; N Rodrigo; D F Hochstrasser; J-C Sanchez
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Publication Detail:
Type:  Congresses; Overall     Date:  2006-06-16
Journal Detail:
Title:  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences     Volume:  840     ISSN:  1570-0232     ISO Abbreviation:  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101139554     Medline TA:  J Chromatogr B Analyt Technol Biomed Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Affiliation:
Neuroproteomics Group, Department of Structural Biology and Bioinformatics, Geneva University, Faculty of Medicine, Geneva, Switzerland. Odile.Carrette@medecine.unige.ch
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / metabolism*
Amino Acid Sequence
Animals
Apolipoproteins E / chemistry,  genetics,  metabolism*
Disease Models, Animal*
Electrophoresis, Gel, Two-Dimensional
Mass Spectrometry
Mice
Mice, Transgenic
Molecular Sequence Data
Proteome*
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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