| Changes of autonomic cardiac profile after a 3-week integrated body weight reduction program in severely obese patients. | |
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MedLine Citation:
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PMID: 12739741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The autonomic control of the heart is abnormal in obese subjects due to a prevalence of sympathetic over parasympathetic limb of the autonomic balance. We evaluated the effects of a short-term (3 weeks) integrated body weight reduction program (consisting of energy restricted diet and high-intensity exercise training) on heart rate variability (HRV) in severely obese, normotensive patients. The HRV was evaluated both in the time and frequency domain over a 18-hour Holter recording period obtained before and at the end of the third week. Three-week body weight reduction program reduced BMI (from 41.4 +/- 4.6 to 39.5 +/- 4.3 kg/m2, -4.6%, p<0.0001) and heart rate (from 77.8 +/- 8.6 to 73.6 +/- 8.7 b/min, p=0.0003). Significant changes in the autonomic profile were observed both in the time and frequency domain (SD of RR interval, SDRR: +16.1%; mean squared successive difference: (MSSD) +16.7%; percentage of RR intervals differing more than 50 msec from the preceding one, pNN50: +31.8%; low frequency oscillation, LF: +17.1%; high frequency oscillation, HF: +/- 18.2%). In conclusion, this study demonstrates that a short-term, integrated body weight reduction program is able to favorably modify the autonomic profile in a population of normotensive, severely obese subjects. The reduction of heart rate and the increase in parasympathetic activity may consistently contribute to a reduction of the risk of cardiovascular morbidity and of sudden cardiac death, still high in this patients' group. |
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Authors:
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M Facchini; G Malfatto; L Sala; G Silvestri; P Fontana; C Lafortuna; A Sartorio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 26 ISSN: 0391-4097 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-05-12 Completed Date: 2004-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 138-42 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Italian Institute for Auxology, IRCCS, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autonomic Nervous System / physiology Body Composition Body Mass Index Diet, Reducing Electrocardiography, Ambulatory Exercise Therapy Female Heart / physiology* Heart Rate / physiology Humans Male Obesity, Morbid / physiopathology*, therapy Weight Loss / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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