Document Detail

Changes of alveolar stability and phospholipids in pulmonary surfactant in acute pancreatitis.
MedLine Citation:
PMID:  6688835     Owner:  NLM     Status:  MEDLINE    
We investigated changes of alveolar stability and phospholipids in the pulmonary surfactant in case of acute pancreatitis induced in rats. Alveolar stability was examined by recording the pressure-volume relationship. The lung volumes during deflation decreased significantly at equivalent transpulmonary pressures, particularly when the pressure was lower than 6 cm H2O. Bubble stability ratio and surface tension indicated that the surface activity of the pulmonary surfactant did decrease in the rats with acute pancreatitis. The alveolar phospholipid content decreased, and the lecithin fraction also decreased significantly, as compared to the control groups. The metabolism of alveolar lecithin was examined following intravenous administration of 14C-labeled palmitate. The biological half-life of the radioactivity of alveolar lecithin was approximately 6 hours in the pancreatitis group, 12 hours in the hepatic ducts ligated group and 14 hours in the simple laparotomy group. The degradation of alveolar lecithin, as well as its synthesis, was accelerated in the rats with acute pancreatitis. However, a decrease in alveolar phospholipid, mainly in lecithin fraction, indicated that the synthesis was inadequate to maintain normal levels and the impairment in pulmonary surfactant may result in a respiratory insufficiency.
K Idegami; K Mori; A Misumi; M Akagi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Japanese journal of surgery     Volume:  13     ISSN:  0047-1909     ISO Abbreviation:  Jpn J Surg     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302176     Medline TA:  Jpn J Surg     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  227-35     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Pancreatitis / metabolism,  physiopathology*
Phosphatidylcholines / metabolism
Phospholipids / metabolism*
Pulmonary Alveoli / metabolism,  physiopathology*
Pulmonary Surfactants / metabolism*
Rats, Inbred Strains
Surface Tension
Total Lung Capacity
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phospholipids; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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