| Changes of IgA(+) Cells and Cytokines in the Cecal Tonsil of Broilers Fed on Diets Supplemented with Vanadium. | |
| | |
MedLine Citation:
|
PMID: 22270623 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The cecal tonsil of broiler is known as a secondary lymphoid tissue, which is involved in antigen-specific humoral immune responses. The purpose of this study was to investigate the effects of dietary vanadium on the tissue distribution and quantity of immunoglobulin A-positive (IgA(+)) cell in the cecal tonsil by immunohistochemistry. Simultaneously, the changes in interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) contents in the cecal tonsil were also quantified by enzyme-linked immunosorbent assay (ELISA). A total of 420 one-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet (control diet) or the same diet supplemented respectively with 5, 15, 30, 45, and 60 mg/kg of vanadium in the form of ammonium metavanadate for 42 days. The results showed that the population of the IgA(+) cells in the cecal tonsil were significantly lower (p < 0.05 or p < 0.01) in the 45 and 60 mg/kg groups than that in the control group. Meanwhile, IL-10, IFN-γ and TNF-α contents in the cecal tonsil were significantly decreased (p < 0.05 or p < 0.01) in the 30, 45 and 60 mg/kg groups in comparison with those of the control group. However, IL-6 content in the cecal tonsil was only decreased (p < 0.05 or p < 0.01) in 60 mg/kg at 14 and 28 days of age. In conclusion, dietary vanadium in excess of 30 mg/kg reduced the numbers of the IgA(+) cells and changed the contents of the abovementioned cytokines in the cecal tonsil, which may finally impact the function of local mucosal humoral immunity in broilers. |
| | |
Authors:
|
Yuanxin Deng; Hengmin Cui; Xi Peng; Jing Fang; Zhicai Zuo; Kangping Wang; Wei Cui; Bangyuan Wu |
Related Documents
:
|
3762333 - A relationship between essential fatty acid and vitamin e deficiency. 1753693 - Vitamin d, within its range of fluctuation in commercial rat diets, does not influence ... 9267583 - Overall and meal-specific macronutrient intake in belgian primary school children. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
|
Title: Biological trace element research Volume: - ISSN: 1559-0720 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, 625014, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reactive oxygen species mediate Jak2/Stat3 activation and IL-8 expression in pulmonary epithelial ce...
Next Document: Large-scale screening of hypothetical metal-organic frameworks.