Document Detail


Changed salt appetite and central angiotensin II-induced cellular activation in rat offspring following hypoxia during fetal stages.
MedLine Citation:
PMID:  20307607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypoxia in pregnancy may induce fetal growth restriction and cause functional abnormalities during development. The present study determined the long-term influence of hypoxia in fetal life on dipsogenic behavior linked to central angiotensin (Ang) network in the offspring rats. Fetal blood pO(2) and body weight were decreased by hypoxia during pregnancy, followed by a postnatal "catch-up" growth. Subcutaneous hypertonic saline or intracerebroventricular Ang II significantly increased salt intake in the offspring prenatally exposed to hypoxia, while water intake was the same between the two groups. Ang II-induced c-fos expression was detected in the paraventricular nuclei, median preoptic nuclei, supraoptic nuclei, and subfornical organ in the brain, in association with reduced forebrain AT(2) receptor protein abundance in the offspring prenatally exposed to hypoxia. Levels of central AT(1) receptor protein were not changed between the two groups. Hypoxia during pregnancy could be linked to developmental problems related to behavioral dysfunctions in body fluid regulations in later life, in association with the change in central angiotensin II-mediated neural activation and expression of the Ang II receptor in the brain.
Authors:
Weili Yang; Caiping Mao; Fei Xia; Jianli Zheng; Aiqing Wang; Liyan Zhu; Rui He; Zhice Xu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-20
Journal Detail:
Title:  Peptides     Volume:  31     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-08-17     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1177-83     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
First Hospital of Soochow University & Perinatal Biology Center, Soochow University, Suzhou 215123, China.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / pharmacology*
Animals
Appetite / drug effects*
Drinking / drug effects
Eating / drug effects
Female
Fetal Hypoxia / physiopathology*
Male
Pregnancy
Prosencephalon / metabolism
Proto-Oncogene Proteins c-fos / biosynthesis
Rats
Rats, Sprague-Dawley
Receptor, Angiotensin, Type 1 / metabolism
Receptor, Angiotensin, Type 2 / metabolism
Saline Solution, Hypertonic / pharmacology
Sodium Chloride / metabolism*
Grant Support
ID/Acronym/Agency:
HL090920/HL/NHLBI NIH HHS; R01 HL090920/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Receptor, Angiotensin, Type 1; 0/Receptor, Angiotensin, Type 2; 0/Saline Solution, Hypertonic; 11128-99-7/Angiotensin II; 7647-14-5/Sodium Chloride
Comments/Corrections

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