| Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study. | |
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MedLine Citation:
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PMID: 21975338 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background The purpose of this study was to evaluate telomerase activity in peripheral whole blood from head and neck squamous cell carcinoma (HNSCC) patients as a biomarker for diagnosis of HNSCC or detection of recurrence during follow-up. Materials and methods Telomerase activity was measured from peripheral whole blood extracts by telomerase repeat amplification protocol (TRAP) in HNSCC patients before and after surgery and in a control group. Sixty-two HNSCC patients and 42 control subjects were included. Results Telomerase activity was found in 41 out of 62 (66.1%) HNSCC patients before surgery and in 8 out of 42 (19.0%) controls (p<0.001). Among 41 HNSCC patients who showed positive telomerase activity before surgery, 32 (78.1%) showed a conversion of telomerase activity to negative after surgery. In follow-up, 6 out of 8 (75%) showed conversion of telomerase activity from negative to positive after recurrence. Telomerase activity was changed to negative in 4 out of 6 (66%) recurred patients with positive telomerase activity after second surgery. Conclusion The telomerase activity in peripheral whole blood extracts of HNSCC patients might be a useful biomarker for detecting recurrence after treatment. Further study with larger sample size using a more sensitive detection method of telomerase activity is necessary to verify these results. |
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Authors:
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Y S Lee; K Tae; S H Lee; S H Cho; J H Jeong; H J Min; Y B Ji |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico Volume: 13 ISSN: 1699-3055 ISO Abbreviation: Clin Transl Oncol Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101247119 Medline TA: Clin Transl Oncol Country: Italy |
Other Details:
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Languages: eng Pagination: 747-53 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Head and Neck Surgery, College of Medicine, Hanyang University, Haengdang-dong 17, Seongdong-gu, Seoul 133-792, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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