Document Detail

Change of seizure frequency in pregnant epileptic women.
MedLine Citation:
PMID:  6411866     Owner:  NLM     Status:  MEDLINE    
The effect of pregnancy on seizure frequency was monitored prospectively in 136 pregnancies of 122 epileptic women. Pregnancy did not influence the seizure frequency in 68 pregnancies (50%). In 50 pregnancies (37%) the number of seizures increased during pregnancy or puerperium. The seizure frequency decreased in 18 pregnancies (13%). In 34 out of 50 pregnancies (68%) the increase was associated with non-compliance with the drug regimen or sleep deprivation. In seven out of 18 pregnancies (39%) improvement was related to correction of non-compliance or sleep deprivation during the pregestational nine months. Insufficiently low plasma concentrations of antiepileptic drugs were found in 47% of the women with uncontrolled epilepsy during pregnancy. The course of epilepsy during pregnancy is primarily influenced by non-compliance, sleep deprivation during pregnancy, and inadequate therapy before and during pregnancy. With good medical attention pregnancy itself seems to have only a minimal influence on the course of epilepsy.
D Schmidt; R Canger; G Avanzini; D Battino; C Cusi; G Beck-Mannagetta; S Koch; D Rating; D Janz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  46     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  751-5     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / administration & dosage*
Epilepsies, Partial / diagnosis
Epilepsy / diagnosis*,  drug therapy
Epilepsy, Temporal Lobe / diagnosis
Patient Compliance
Pregnancy Complications / diagnosis*,  drug therapy
Prospective Studies
Puerperal Disorders / diagnosis
Sleep Deprivation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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