| Change of nuclear size in monolayer cells from embryonic mouse brain under the influence of cytosine-arabinoside. | |
| | |
MedLine Citation:
|
PMID: 1229249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The influence of cytosine-arabinoside (ara-C) on the nuclear size of monolayer cells from mouse brains were studied by quantitative analysis with the Quantimet (area measurement) and linear analysis with the Digiscan. Ara C (0,1; 1,0; 10,0 mug/ml) causes a significant nuclear enlargement, depending on the dose of 16%, 30% and 35% respectively and at the same time a decrease in cell density and an inhibition of mitotic activity. The size-distribution graph is altered by ara-C: the graph flattens and widens at the base. Moreover, in the case of 10,0 mug ara-C/ml a pronounced graph shoulder is visible in the small nuclear size region which can be interpreted as a slight accumulation of small nuclei. The nuclear enlargement is possibly due to an accumulation of shortchain polynucleotides. |
| | |
Authors:
|
B Zimmermann; H Adhami |
Related Documents
:
|
10223179 - Colonic epithelial cell activation and the paradoxical effects of butyrate. 23470279 - Histoplanimetrical study on the relationship between invasion of indigenous bacteria in... 3211129 - Localization and expression of mrna for a macronuclear-specific histone h2a variant (hv... 20569199 - Genomic tagging reveals a random association of endogenous ptdins5p 4-kinases iialpha a... 7496399 - The distribution of a spliceosome protein in cereal (triticeae) interphase nuclei from ... 20951589 - The role of chromatin structure in cell migration. 12719239 - An experimental and theoretical analysis of ultrasound-induced permeabilization of cell... 9846949 - Comparative aspects of meiotic cell cycle control in mammals. 18468679 - Cddo-imidazolide mediated inhibition of malignant cell growth in waldenström macroglob... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Zeitschrift für mikroskopisch-anatomische Forschung Volume: 89 ISSN: 0044-3107 ISO Abbreviation: Z Mikrosk Anat Forsch Publication Date: 1975 |
Date Detail:
|
Created Date: 1976-09-01 Completed Date: 1976-09-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0413637 Medline TA: Z Mikrosk Anat Forsch Country: GERMANY, EAST |
Other Details:
|
Languages: eng Pagination: 632-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / cytology* Cell Nucleus / drug effects Cells, Cultured Cytarabine / pharmacology* Embryo, Mammalian Embryo, Nonmammalian Neurons / drug effects |
| Chemical | |
Reg. No./Substance:
|
147-94-4/Cytarabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The postnatal development of the hypoglossal nucleus in the rat
Next Document: 3H-tyrosin incorporation by foregut entoderm, as an additional proof of extra-glandular presence of ...