Document Detail

Change of nuclear size in monolayer cells from embryonic mouse brain under the influence of cytosine-arabinoside.
MedLine Citation:
PMID:  1229249     Owner:  NLM     Status:  MEDLINE    
The influence of cytosine-arabinoside (ara-C) on the nuclear size of monolayer cells from mouse brains were studied by quantitative analysis with the Quantimet (area measurement) and linear analysis with the Digiscan. Ara C (0,1; 1,0; 10,0 mug/ml) causes a significant nuclear enlargement, depending on the dose of 16%, 30% and 35% respectively and at the same time a decrease in cell density and an inhibition of mitotic activity. The size-distribution graph is altered by ara-C: the graph flattens and widens at the base. Moreover, in the case of 10,0 mug ara-C/ml a pronounced graph shoulder is visible in the small nuclear size region which can be interpreted as a slight accumulation of small nuclei. The nuclear enlargement is possibly due to an accumulation of shortchain polynucleotides.
B Zimmermann; H Adhami
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für mikroskopisch-anatomische Forschung     Volume:  89     ISSN:  0044-3107     ISO Abbreviation:  Z Mikrosk Anat Forsch     Publication Date:  1975  
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413637     Medline TA:  Z Mikrosk Anat Forsch     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  632-9     Citation Subset:  IM    
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MeSH Terms
Brain / cytology*
Cell Nucleus / drug effects
Cells, Cultured
Cytarabine / pharmacology*
Embryo, Mammalian
Embryo, Nonmammalian
Neurons / drug effects
Reg. No./Substance:

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