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Change of the initiation time of blood coagulation in pregnancy from 10-months to postpartum.
MedLine Citation:
PMID:  22475689     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We measured the time of initiation of blood coagulation (Ti) from pregnancy 10-months (36~40 weeks) till 1-month after delivery, paying particular attention to the very early postpartum period, using a damped oscillation rheometer that is approximately 160 times more sensitive than the Thromboelastogram® to evaluate the risk of thrombus formation. Blood samples were obtained from healthy volunteers at pregnancy 10-month, 1-hour, 3-hours, 4-days, 7-days, 3-weeks and 1-month after delivery. Ti values at pregnancy 10-month, 1-hour, 3-hours, 4-days, 7-days, 3-weeks, 1-month after delivery and in non-pregnant females were 20.4 ± 2.2, 11.7 ± 1.6, 13.2 ± 3.1, 17.2 ± 2.0, 20.2 ± 1.6, 21.4 ± 4.0, 24.6 ± 3.6, and (25.0 ± 3.4) minutes, respectively. Ti was significantly shorter at pregnancy 10-month, 1-hour, 3-ours, 4-days, 7-days and 3-weeks after delivery than in non-pregnant females. These data show that the blood of pregnant females is more hypercoagulable than non-pregnant females from pregnancy 10-month until 3-weeks post delivery, suggesting that they are at high risk of VTE after discharge from hospital.
Authors:
Toshiaki Sagesaka; Hiroyuki Funabashi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  -     ISSN:  1875-8622     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, International University of Health and Welfare, Atami Hospital, Atami-shi, Shizuoka, Japan.
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