Document Detail


Change in the proportion of T and B lymphocytes in human malignant neoplasia in relation to the clinical stage.
MedLine Citation:
PMID:  1081657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Formation of spontaneous (E--erythrocyte) and immune (EAC--erythrocyte, antibody, complement) rosettes of sheep red blood cells (SRBC) with peripheral blood T and B lymphocytes, respectively, was used for quantitative assessment of these lymphocytes populations in tumor patients and control subjects. Relative counts of T and B lymphocytes have been correlated with lymphocyte survival in short-term cultures using standard subtoxic doses of phytohemagglutinin (PHA). The mean values and SE in normal control subjects for E rosettes (T lymphocytes) were 72.8 +/- 1.2%, for EAC rosettes (B lymphocytes) 23.8 +/- 2.5% of lymphocyte population. The survival of lymphocytes in short-term cultures with PHA in control subjects was 55.3 +/- 1.1%. In tumor patients the counts of E, EAC rosettes and percentage of lymphocyte survival in short-term PHA cultures were dependent upon the clinical stage. In patients with localized tumors the values were similar to controls. In patients where dissemination of the tumorous process could be ascertained a decrease of T lymphocyte counts, an increase of B lymphocyte counts and a higher survival of peripheral blood lymphocytes in short-term cultures with PHA was found.
Authors:
O Babusíková; L' Novotná; S Korec; K Schneková; D Turková; M Havránková; K Plentová
Related Documents :
15589737 - Intragraft distribution of lymphocytes expressing beta7 integrins after small bowel tra...
3083067 - Focal lymphocytic infiltration in the human labial salivary glands: a postmortem study.
1090517 - The bursa dependence of chicken thymus-derived lymphocyte surface immunoglobulin.
6222467 - Cytochemistry of normal lymphocyte subsets defined by monoclonal antibodies and immunoc...
20015987 - Comparative immunogenicity of subtype a human immunodeficiency virus type 1 envelope ex...
24111867 - Preparation and identification of a novel antibody against human cdc7 kinase.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  22     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-13     Completed Date:  1976-02-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  413-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes* / immunology
Cell Survival
Complement System Proteins
Humans
Immune Adherence Reaction
Immunity, Cellular
Lectins
Neoplasms / immunology*
Rats
T-Lymphocytes* / immunology
Chemical
Reg. No./Substance:
0/Lectins; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of L-3-methoxytyrosine on monoamine synthesis in rat brain.
Next Document:  Migration inhibition of peritoneal cells and PHA lymphocyte toxicity in rats during methylcholanthre...