| Change in high-density lipoprotein cholesterol and incident coronary heart disease in apparently healthy male physicians. | |
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MedLine Citation:
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PMID: 19064020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The association between change in high-density lipoprotein (HDL) cholesterol and risk of subsequent coronary heart disease (CHD) is unclear. Change in HDL cholesterol was calculated in a prospective cohort of 4,501 male physicians enrolled in the Physician's Health Study (PHS) I who had HDL cholesterol measured in 1982 and again approximately 14 years later. Subjects were divided into categories of those with a decrease (>or=-2.5 mg/dl), no change (change -2.5 to 2.5 mg/dl), a small increase of 2.5 to 12.5 mg/dl, or a large increase of >or=12.5 mg/dl. Cox proportional hazards was used to examine the association between change in HDL cholesterol and incident CHD (confirmed acute myocardial infarction or cardiac death). Hazard ratios (HRs) were adjusted for age, initial HDL cholesterol, diabetes mellitus, hypertension, non-HDL cholesterol, and history of cholesterol medication. Compared with subjects with a decrease in HDL cholesterol, multivariable-adjusted HRs for CHD were 0.66 (95% confidence interval [CI] 0.40 to 1.09) in subjects with no change, 0.56 (95% CI 0.35 to 0.89) for subjects with an increase of 2.5 to 12.5 mg/dl, and 0.43 (95% CI 0.23 to 0.83) for subjects with an HDL cholesterol increase >or=12.5 mg/dl. In conclusion, our findings were consistent with an inverse graded relation between 14-year increase in HDL cholesterol and risk of subsequent CHD. |
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Authors:
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Catherine Rahilly-Tierney; Thomas S Bowman; Luc Djoussé; Howard D Sesso; J Michael Gaziano |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of cardiology Volume: 102 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-09 Completed Date: 2008-12-18 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1663-7 Citation Subset: AIM; IM |
Affiliation:
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Massachusetts Veterans Epidemiology and Research Information Center, Office of Research and Development, Department of Veterans Affairs, Boston, Massachusetts, USA. catherine.rahilly@va.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cholesterol, HDL / blood* Cohort Studies Coronary Disease / blood*, epidemiology Humans Male Middle Aged Multivariate Analysis Physicians Risk |
| Grant Support | |
ID/Acronym/Agency:
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CA-097193/CA/NCI NIH HHS; CA-34944/CA/NCI NIH HHS; CA-40360/CA/NCI NIH HHS; HL-26490/HL/NHLBI NIH HHS; HL-34595/HL/NHLBI NIH HHS; K01 HL-70444/HL/NHLBI NIH HHS; R01 CA097193-01/CA/NCI NIH HHS; R01 CA097193-02/CA/NCI NIH HHS; R01 CA097193-03/CA/NCI NIH HHS; R01 CA097193-04/CA/NCI NIH HHS; R01 CA097193-05/CA/NCI NIH HHS; R01 CA097193-06A1/CA/NCI NIH HHS; R01 CA097193-07/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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