Document Detail

Change in health-related quality of life in the first 18 months after lower limb amputation: a prospective, longitudinal study.
MedLine Citation:
PMID:  23624575     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe changes in health-related quality of life in people with lower limb amputation, from time of amputation to 18 months, taking into consideration the influence of age and walking distance. In addition, quality of life for people with amputation is compared with the Dutch population norm values.
DESIGN: Multicentre, longitudinal study.
SUBJECTS: All people undergoing first amputation: 106 were referred, of whom 82 were included, mean age 67.8 years (standard deviation; SD 13.0), 67% men. A total of 35 remained in the study at 18 months.
METHODS: Dutch language RAND-36 questionnaire (Research and Development Corporation measure of Quality of Life) was completed at time of amputation, 6 and 18 months after amputation.
RESULTS: Over time, a significant improvement was seen in physical function, social function, pain, vitality, and perceived change in health (all p < 0.001). Subjects over 65 years of age had a poorer outcome compared with people <65 years for physical function only (p < 0.001). Walking distance was associated with improved scores in social function (p = 0.047).
CONCLUSION: Quality of life improved significantly in 5 of 7 domains investigated; most change occurred in the first 6 months. Physical function remained well below population norm values. Different domains may be affected in different ways for older and younger age groups, but this requires further research.
Lauren V Fortington; Pieter U Dijkstra; Joline C Bosmans; Wendy J Post; Jan H B Geertzen
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of rehabilitation medicine     Volume:  45     ISSN:  1651-2081     ISO Abbreviation:  J Rehabil Med     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-24     Completed Date:  2013-11-11     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  101088169     Medline TA:  J Rehabil Med     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  587-94     Citation Subset:  IM    
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MeSH Terms
Amputation / psychology*
Health Status Indicators
Independent Living
Longitudinal Studies
Lower Extremity
Middle Aged
Mobility Limitation*
Models, Statistical
Outcome Assessment (Health Care)
Prospective Studies
Quality of Life*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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