| Change in haemoglobin concentration, haematocrit and vasoactive hormones in haemodialysis patients with erythropoietin-associated hypertension. | |
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MedLine Citation:
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PMID: 8034437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The changes in haemoglobin concentration, haematocrit, plasma renin activity (PRA) and atrial natriuretic peptide (ANP) were studied in 10 haemodialysis patients with erythropoietin-associated hypertension. All patients received intravenously 1500 IU of recombinant human erythropoietin (rHuEPO) thrice weekly for 24 weeks. Treatment with rHuEPO induced significant rises in haemoglobin concentration (p < 0.001) and haematocrit (p < 0.01). However, the difference between post- and pretreatment levels of haemoglobin (delta Hb) was not correlated with that between post- and pre-treatment mean blood pressure (delta MBP). No correlation was found between delta Ht (difference between post- and pre-treatment values of haematocrit) and delta MBP. These results indicate that elevation of the haematocrit and haemoglobin concentration of haemodialysis patients does not necessarily lead to an increase in blood pressure. In these patients, no significant differences were observed in PRA and ANP, comparing pre-treatment values with those measured 4, 8, 12 or 24 weeks after commencing rHuEPO. This suggests that neither PRA nor ANP play a central role in the pathogenesis of rHuEPO-induced hypertension. |
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Authors:
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I Sasagawa; T Nakada; T Hashimoto; Y Kubota; H Suzuki; T Sawamura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International urology and nephrology Volume: 26 ISSN: 0301-1623 ISO Abbreviation: Int Urol Nephrol Publication Date: 1994 |
Date Detail:
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Created Date: 1994-08-17 Completed Date: 1994-08-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: HUNGARY |
Other Details:
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Languages: eng Pagination: 237-43 Citation Subset: IM |
Affiliation:
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Department of Urology, Yamagata University, School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrial Natriuretic Factor / blood* Erythropoietin / adverse effects*, blood Female Hematocrit Hemoglobins / analysis* Humans Hypertension / etiology* Kidney Failure, Chronic / physiopathology Male Middle Aged Renal Dialysis* Renin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 11096-26-7/Erythropoietin; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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