Document Detail

Change in coronary flow reserve on transthoracic Doppler echocardiography after a single high-fat meal in young healthy men.
MedLine Citation:
PMID:  11926787     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: High-fat meals and elevated triglyceride levels are associated with cardiovascular disease. In recent studies of brachial artery vasoactivity, a single high-fat meal reduced endothelial function in young healthy men. It is unknown whether coronary microcirculation is affected after high-fat meals. OBJECTIVE: To evaluate change in coronary flow reserve after a single high-fat meal. DESIGN: Controlled interventional study. SETTING: University hospitals. PATIENTS: 15 young healthy men (mean age [+/-SD], 29 +/- 4 years). INTERVENTION: Coronary flow reserve was determined by using transthoracic Doppler echocardiography before and after consumption of a high-fat meal in all 15 men and before and after consumption of a low-fat meal in 5 of 15 men. MEASUREMENTS: Coronary flow reserve, lipid levels, and hemodynamic characteristics. RESULTS: In all men, triglyceride levels increased significantly from baseline 5 hours after the high-fat meal, from 1.1 mmol/L to 2.8 mmol/L (100 mg/dL to 250 mg/dL) (P < 0.001). Average coronary flow reserve was 4.02 before and 3.30 5 hours after the high-fat meal (decrease, 18% [95% CI, 13% to 23%]). In the 5 men who received both meals, mean coronary flow reserve decreased by 0.79 after the high-fat meal and increased by 0.07 after the low-fat meal (difference, -0.86 [CI, -1.36 to -0.37]; P = 0.03). Mean triglyceride levels increased by 1.6 mmol/L (140 mg/dL) after the high-fat meal and 0.1 mmol/L (10 mg/dL) after the low-fat meal (difference, 1.5 mmol/L [CI, 0.3 to 2.7 mmol/L], 130 mg/dL [CI, 23 to 236 mg/dL]; P = 0.03). CONCLUSIONS: Coronary flow reserve decreased after a single high-fat meal in young healthy men. High-fat meals may be detrimental to coronary microcirculation.
Takeshi Hozumi; Marc Eisenberg; Kenichi Sugioka; Aravind R Kokkirala; Hiroyuki Watanabe; Masakazu Teragaki; Junichi Yoshikawa; Shunichi Homma
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  136     ISSN:  1539-3704     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-02     Completed Date:  2002-04-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  523-8     Citation Subset:  AIM; IM    
Columbia University, New York, New York 10032, USA.
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MeSH Terms
Blood Flow Velocity / drug effects
Coronary Circulation / drug effects*
Coronary Vessels / ultrasonography
Dietary Fats / adverse effects*
Echocardiography, Doppler
Endothelium, Vascular / drug effects
Lipids / blood
Microcirculation / drug effects
Risk Factors
Triglycerides / blood
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Lipids; 0/Triglycerides
Summary for patients in:
Ann Intern Med. 2002 Apr 2;136(7):I41   [PMID:  11926809 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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