| Change in contents of biologically active sphingolipids modulating cell growth and survival in hepatoma 27 compared to rat liver. | |
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MedLine Citation:
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PMID: 15193122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contents of bioactive sphingolipids (sphingomyelin, ceramide, glucosyl- and lactosylceramides, gangliosides) were studied in rat hepatoma 27 and rat liver. The amounts of sphingomyelin, ceramide, and glucosyl- and lactosylceramides were about twofold and that of gangliosides was about 3.5-fold increased in the tumor compared to normal tissue. Since sphingomyelin promotes angiogenesis, glucosyl- and lactosylceramides stimulate proliferation, gangliosides inhibit apoptosis, but ceramides suppress proliferation and stimulate apoptosis, it is obvious that the balance of these effectors in hepatoma 27 moves with the tumor growth. |
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Authors:
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A G Kandyba; V A Kobliakov; O G Somova; E V Dyatlovitskaya |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry. Biokhimii͡a Volume: 69 ISSN: 0006-2979 ISO Abbreviation: Biochemistry Mosc. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-06-14 Completed Date: 2005-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376536 Medline TA: Biochemistry (Mosc) Country: United States |
Other Details:
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Languages: eng Pagination: 497-500 Citation Subset: IM |
Affiliation:
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Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation Cell Survival Ceramides / metabolism Chromatography, Thin Layer Liver / cytology, metabolism* Liver Neoplasms, Experimental / metabolism*, pathology Rats Sphingolipids / metabolism* Sphingomyelins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Ceramides; 0/Sphingolipids; 0/Sphingomyelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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